Ph.D. (2000) Stanford University
Postdoctoral Research: Lawrence Berkeley National Laboratory/University of California, Berkeley, 2000-2003
Lab website: http://gasch.genetics.wisc.edu/
Address: 3426 Genetics/Biotech
Research InterestsElucidating the role, regulation, and evolution of eukaryotic stress responses.
Research FieldsComputational, Systems & Synthetic Biology
Evolutionary & Population Genetics
Gene Expression Genomics & Proteomics
All organisms must be able to sense and respond to their environment and defend themselves against environmental stress. Cells respond to acute environmental stress by mounting a multi-faceted cellular response that typically includes coordinated changes in transcription and translation, protein function, and metabolic fluxes, along with transient arrest of growth and cell cycle progression. How these disparate physiological processes are coordinated is poorly understood but likely critical for surviving and acclimating to stressful conditions.
The Gasch Lab uses modern techniques in comparative and functional genomics, computational and systems biology, and genetics and molecular biology to study how cells sense their environment, detect when there is a problem, and then coordinate a multi-faceted response to protect themselves. We study these topics in the budding yeast Saccharomyces cerevisiae as a model for basic biology. Because defects in sensing and responding to cellular stress are linked to many human diseases, and because much of yeast physiology is similar to human cells, our research is generating important insights into how normal cells function and when problems cause disease.
We are also interested in the relationship between genotype and phenotype, and how environmental responses evolve in natural populations. We study these questions at a mechanistic level in wild isolates of budding yeast. We also leverage evolution and natural diversity to engineer new traits aimed at producing sustainable and economical biofuels from cellulosic materials. As part of the DOE-funded Great Lakes Bioenergy Research Center (GLBRC), our lab is addressing critical bottlenecks in microbial fuel and chemical production.
Dosage compensation can buffer copy-number variation in wild yeast. Hose J, Yong CM, Sardi M, Wang Z, Newton MA, Gasch AP. Elife. 2015 May 8;4.
Ecological and Genetic Barriers Differentiate Natural Populations of Saccharomyces cerevisiae. Clowers KJ, Heilberger J, Piotrowski JS, Will JL, Gasch AP.Mol Biol Evol. 2015 May 6.
Pathway connectivity and signaling coordination in the yeast stress-activated signaling network. Chasman D, Ho YH, Berry DB, Nemec CM, MacGilvray ME, Hose J, Merrill AE, Lee MV, Will JL, Coon JJ, Ansari AZ, Craven M, Gasch AP. Molecular Systems Biol. 2014 Nov 19;10:759.
A dynamic model of proteome changes reveals new roles for transcript alteration in yeast. Lee MV, Topper SE, Hubler SL, Hose J, Wenger CD, Coon JJ, Gasch AP. Molecular Systems Biol. 2011 Jul 19;7:514.
Multiple means to the same end: the genetic basis of acquired stress resistance in yeast. Berry DB, Guan Q, Hose J, Haroon S, Gebbia M, Heisler LE, Nislow C, Giaever G, Gasch AP. PLoS Genet. 2011 Nov;7(11):e1002353.