Ph.D., University of Michigan, 1973
Postdoctoral Research: Harvard Medical School and University of Wisconsin- Madison
Address: 5507 Biochemistry
Department: Biochemistry and Medical Microbiology
Genetic and biochemical studies of peripheral B lymphocyte development
Human and Mammalian
Our laboratory studies B lymphocyte development. We discovered a B cell-intrinsic locus, Bcmd-1 (B cell maturation defect), that regulates the peripheral B lymphocyte life span. When Bcmd-1 is mutated, peripheral B lymphocytes die prematurely, rendering the animal profoundly B cell deficient and incapable of producing memory antibody responses. Current genetic experiments are mapping Bcmd-1 and constructing a congenic strain for future in vivo studies of Bcmd-1 function. A candidate locus is under investigation. Current biochemical experiments are testing growth factor receptor signal transduction pathways and the synthesis of apoptosis inhibitory proteins in wild-type and Bcmd-1-mutant B cells, with the goal of identifying the biochemical pathway that is disrupted by the Bcmd-1 mutation.
J., D. Dyment, D. Sadovnick, N. Risch, C. Hayes, G. Ebers, and the
Canadian Collaborative Study Group. 2000. Genetic analysis of vitamin D
related genes in Canadian multiple sclerosis patients. Neurology,
Nashold, F.E., D.J. Miller, and C.E. Hayes. 2000. 1,25-Dihydroxyvitamin D3 decreases macrophage accumulation in the CNS of mice with experimental autoimmune encephalomyelitis. J. Neuroimmunology 103:171-179.
Lentz, V. M., C. E. Hayes and M. P. Cancro. 1998. Bcmd decreases the lifespan of B-2 but not B-1 cells in A/WySnJ mice. J. Immunol. 160:3743-3747.
Cancro, M. P., D. M. Allman, C. E. Hayes, V. M. Lentz, R. G. Fields, and M. Tomayko. 1998. B cell maturation and selection at the marrow-periphery interface. Immunological Res. 17:3-11.