Ph.D., University of New Hampshire, 1996
Postdoctoral Research: University of Wisconsin — Madison
Lab website: http://asap.ahabs.wisc.edu/
Address: 4434 Genetics/Biotech
Research InterestsWe focus on systems-scale evolutionary genomics of agriculturally, biomedically and industrially significant bacteria.
Research FieldsDisease Biology
Computational, Systems & Synthetic Biology
Evolutionary & Population Genetics
Genomics & Proteomics
Our research is directed at understanding
the molecular evolution of complex traits like virulence and host range.
Our work focuses on the Enterobacteriaceae, a bacterial family with
members occupying diverse environmental niches including plant and
animal hosts with lifestyles ranging from mutualism to pathogenesis. We
use both computational and experimental approaches to study the rates,
patterns, mechanisms and phenotypic consequences of genome-scale
Some of our current areas of research are:
1) Specialization in either plant or animal hosts
2) Recombination within and between species, populations and strains
3) Rates and patterns of genome rearrangement
4) Regulatory evolution and energy metabolism
5) Evolution of chemotaxis and signaling systems
We also develop tools and resources for genome analysis, including a multiple genome alignment and visualization system, and an interactive web-based genome database and analysis platform. Tools developed in our group are publicly distributed for use by the larger research community.
R. Mau, J.D. Glasner, A. Darling and N.T.
Perna. 2006. Genome-wide detection and analysis of homologous
recombination among sequenced strains of Escherichia coli. Genome Biol.
B.D. Anderson, M.C. Gilson, A.A. Scott, B.S. Biehl, J.D. Glasner, G. Rajashekara, G.A. Splitter and N.T. Perna. 2006. CGHScan: Finding Variable Regions Using High-Density Microarray Comparative Genomic Hybridization Data. BMC Genomics . 7:91.
J.D. Glasner, M.C. Rusch, P. Liss, G. Plunkett III, E. L. Cabot, A. Darling, B.D. Anderson, P. Infield-Harm, M.C. Gilson and N.T. Perna. 2006. ASAP: A resource for annotating, curating, comparing, and disseminating genomic data. Nucleic Acids Res. 1;34(Database issue):D41-5.
S. Yang, N.T. Perna, D.A. Cooksey, Y. Okinaka, S.E. Lindow, A.M. Ibekwe, N.T. Keen and C.-H. Yang. 2004. Genome-wide identification of plant up-regulated genes of Erwinia chrysanthemi 3937 using GFP based IVET Leaf Arrays. MPMI. 17:999-1008.
A. Darling, B. Mau, F.R. Blattner and N.T. Perna. 2004. Mauve, Muliple Genome Alignment. Genome Research. 14:1394-1403.