Oliver Smithies Professor of Genetics
Ph.D., The Johns Hopkins University, 1968
Postdoctoral Research: McArdle Laboratory for Cancer Research, University of Wisconsin
We are interested in the genomics of
bacteria. Having sequenced E. coli K-12 we have now turned to large
scale functional genomics of E. coli through DNA chip analysis of global
gene expression and by phenotypic analysis of conditional knock-out
We are also interested in hypothesis driven comparative and evolutionary genomics by sequencing strains closely related to K-12. The first strain sequenced for comparison is E. coli 0157:H7, the “hamburger strain.” Future studies include enteropathogenic, enterotoxigenic, enteroaggregative and uropathogenic strains of E. coli, as well E. coli K1, a cause of neonatal sepsis and miningitis. We are also planning to sequence Yersinia Pestis (plague), Shigella flexneri (dysentary), and Salmonella typhi (typhoid fever). It turns out that many virulence determinants of the different pathogens are similar pathogens, so this approach will allow identification of a “pathosphere” of the virulence genes that make up the pathogenic potential of these bacteria. Other lab interests include bioinformatics, technology development, and genetic engineering/re-engineering of bacterial genomes.
Dr. Blattner is no longer accepting graduate students.
Hensel, M., J. E. Shea, A. J.
Baumler, C. Gleeson, F. Blattner and D. W. Holden. 1997. Analysis of
the boundaries of Salmonella pathogenicity island 2 and the
corresponding chromosomal region of Escherichia coli K-12. J Bacteriol
Blattner, F.R., G.R. Plunkett, C. A. Bloch, N. T. Perna, V. Burland, M. RIley, J. Collado-Vides, J. D. Glasner, C. K. Rode, G. F. Mayhew, et al. 1997. The complete genome sequence of Escherichia coli K-12 science 277:1453-74.
Fernandez, D.E., Heck, G.R., Perry, S.E., Patterson, S.E., Bleecker, A.B., and S Fang. (2000) The embryo MADS domain factor AGL15 acts post-embryonically: inhibition of perianth senescence and abscission via constitutive expression. Plant Cell 12:183-19.