Aaron Hoskins

Position title: Assistant Professor

Email: ahoskins@wisc.edu

Phone: 608-890-3101

RNA splicing, gene expression, fluorescence microscopy, RNA/protein complexes

2214 Biochemical Sciences Building
Lab website
Ph.D., Massachusetts Institute of Technology, 2006
Research Interests
Gene Expression, RNA, Splicing, Biophysics
Research Fields
Biochemistry, Single-Molecule Biophysics, Yeast Genetics, Chemical Biology, Molecular Biology

Research Description:
My laboratory is interested in how a molecular machine called the spliceosome functions and is regulated during gene expression. In particular, we are interested in how the spliceosome identifies particular locations within introns before they are removed during pre-mRNA splicing. We use a combination of genetic, biochemical, and biophysical approaches to study the spliceosome in vitro and in cells.

Representative Publications:
Search PubMed for more publications by Aaron Hoskins

Kaur H, van der Feltz C, Sun Y, Hoskins AA. Network theory reveals principles of spliceosome structure and dynamics. Structure. 2022 Jan 6;30(1):190-200.e2. doi: 10.1016/j.str.2021.09.003. Epub 2021 Sep 29. PMID: 34592160; PMCID: PMC8741635.

Beier DH, Carrocci TJ, van der Feltz C, Tretbar US, Paulson JC, Grabowski N, Hoskins AA. Dynamics of the DEAD-box ATPase Prp5 RecA-like domains provide a conformational switch during spliceosome assembly. Nucleic Acids Res. 2019 Nov 18;47(20):10842-10851. doi: 10.1093/nar/gkz765. PMID: 31712821; PMCID: PMC6846040.