Ahmed Mahmoud

Position title: Assistant Professor

Email: aimahmoud@wisc.edu

Address:
Cell and Regenerative Biology
Mammalian cardiac regeneration

Address
1111 Highland Avenue, Room 4557, Madison WI 53705
Department
Cell and Regenerative Biology
Research Interests
Heart failure, ischemic heart disease, cardiac regeneration
Research Fields
Mammalian cardiac regeneration
Lab Website
https://mahmoud.crb.wisc.edu

Heart failure is the leading cause of death in the world due to the inability of the adult mammalian heart to regenerate following injury. Lower vertebrates, such as zebrafish are capable of complete and efficient regeneration of the myocardium following injury. Similarly, we demonstrated that neonatal mice are capable of regenerating their hearts within a short period after birth but lose this potential in the first week of life. Adult mammals lack this cardiac regeneration potential, thus our overarching goal in the laboratory is to dissect the molecular underpinnings of regeneration in the neonatal heart so that we can explore potential avenues to activate this process in adult humans.

Our goals are to identify the transcriptional and epigenetic networks that govern cardiomyocyte dedifferentiation and proliferation through studying evolutionarily conserved mechanisms of regeneration. These studies could aid in converting adult cardiomyocytes to a more proliferative and regenerative state. In addition, we aim to identify the microenvironment signals that regulate mammalian heart regeneration by studying the interplay of nerves as well as extracellular factors during mammalian heart regeneration. We use multidisciplinary approaches including genomics, proteomics, and mouse genetics in addition to molecular and cellular technologies to address these questions.


Representative Publications:

Search PubMed for more publications by Ahmed Mahmoud

2023

Salamon, R.J., Halbe, P., Kasberg, W., Bae, J., Audhya, A., Mahmoud, A.I.*. Parasympathetic and sympathetic axons are bundled in the cardiac ventricles and undergo physiological reinnervation during heart regeneration. iScience, In Press. (*corresponding author).

Salamon, R.J., McKeon, M.C., Bae, J., Zhang, X., Paltzer, W.G., Wanless, K.N., Schuett, A.R., Nuttall, D.J., Nemr, S.A., Sridharan, R., Lee, Y., Kamp, T.J., Mahmoud, A.I.*. LRRC10 regulates mammalian cardiomyocyte cell cycle during heart regeneration. npj Regenerative Medicine, 2023 Jul 28;8(1):39. (*corresponding author).

Aballo, T.J., Roberts, D.S., Bayne, E.F., Zhu, W., Walcott, G., Mahmoud, A.I., Zhang, J., Ge, Y. Integrated proteomics reveals alterations in sarcomere composition and developmental processes during postnatal swine heart development. Journal of Molecular and Cellular Cardiology, 2023 Mar; 176:33-40.

2022

Brandt E.B., Mahmoud A.I.* (2022) Quantifying CardiomyocyteProliferation and Nucleation to Assess Mammalian Cardiac Regeneration. Methods in Molecular Biology, vol 2485. (*corresponding author).

Salamon, R.J., Mahmoud, A.I.*. Bridging the communication gap: cardiomyocytes reciprocate sympathetic nerve signalling. Journal of Physiology, 2022 May 25. (*corresponding author).

2021

Bae, J., Paltzer, W.G., Mahmoud, A.I.*. The role of metabolism in heart failure and regeneration. Frontiers in Cardiovascular Medicine, 2021 Jul 16;8:702920. (*corresponding author).

Tampakakis, E.*, Mahmoud, A.I.*. The role of hormones and neurons in cardiomyocyte maturation. Seminars in Cell & Developmental Biology, 2021 Oct;118:136-143. (*co-corresponding authors).

Bae, J., Salamon, R.J., Brandt, E.B., Paltzer, W.G., Zhang, Z., Britt, E.C., Hacker, T.A., Fan, J., Mahmoud, A.I.*. Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration. Circulation, May 18;143(20):1973-1986. (*corresponding author)

2020

Salamon, R.J., Zhang, Z., Mahmoud, A.I.*. Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging. Journal of Visualized Experiments, 2020 Mar 17; (157). (*corresponding author).