Jason Peters

Position title: Assistant Professor

Email: jason.peters@wisc.edu

Pharmaceutical Sciences
Roles of bacterial gene networks in antibiotic resistance and biofuel production

Ph.D. in Genetics, University of Wisconsin- Madison
777 Highland Ave Madison, WI 53705
Pharmaceutical Sciences
Research Interests
Roles of bacterial gene networks in antibiotic resistance and biofuel production
Research Fields
Disease Biology, Cell Biology, Computational, systems and synthetic biology, Development, Evolutionary and population genetics, Gene expression, Genomics and proteomics, Bacteria and other microbes

The emergence of bacterial pathogens resistant to most antibiotics—even those of last resort—is an urgent threat to human health, and underscores the need for new antibiotics with novel modes of action (MOA). Antibiotics target essential processes, exerting complex effects on downstream gene networks. The impact of an antibiotic on gene networks—outside of the direct target—not only affects the MOA, but also influences whether drug combinations will be synergistic or antagonistic. Thus, mapping networks of genes involved in essential processes will allow us to identify novel synergistic therapies and define new cellular targets for antibiotics. My work will couple CRISPR-based functional genomics with cross-species analysis to perform a systematic analysis of gene networks, providing pioneering insights into the fundamental mechanisms by which bacteria respond to antibiotics and enable us to develop new strategies to fight bacterial infections. Current projects in the lab include: mapping regulatory networks in Escherichia coli, identifying new cell wall genes in Acinetobacter baumannii, and genetic engineering of Zymomonas mobilis for biofuel production.

Representative Publications:

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Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS. Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi. Nat Microbiol. 2019 Feb;4(2):244-250. doi: 10.1038/s41564-018-0327-z. Epub 2019 Jan 7. PMID: 30617347; PMCID: PMC6424567.