Michael Taylor

Position title: Assistant Professor

Address:
School of Pharmacy, Pharmaceutical Sciences Division
Regulation of CNS angiogenesis and barriergenesis

Address: 777 Highland Ave.
Website: https://apps.pharmacy.wisc.edu/sopdir/michael_taylor/
Education: PhD, University of Washington, Seattle, 2002
Department: School of Pharmacy, Pharmaceutical Sciences Division
Research Interests: Regulation of CNS angiogenesis and barriergenesis
Research Fields: Disease Biology, Cell Biology, Development, Zebrafish

Research Description:
Genetic regulation of CNS angiogenesis and barriergenesis.

Representative Publications:
Lanham, K. A., Nedden, M. L., Wise, V. E. Taylor, M. R., (2022) Genetically-inducible and reversible zebrafish model of systemic inflammation. Biology Open 11(3):bio058559.

Ali Z., Mukwaya A., Biesemeier A., Ntzouni M., Ramskold D., Giatrellis S., Mammadzada P., Cao R., Lennikov A., Marass M., Gerri C., Hildesjö C., Taylor M., Deng Q., Peebo B., del Peso L., Kvanta A., Sandberg R., Schraermeyer U., Andre H., Steffensen J., Lagali N., Cao Y., Kele J., Jensen L. (2019) Intussusceptive vascular remodeling precedes pathological neovascularization. Arteriosclerosis, Thrombosis, and Vascular Biology 39:1402-18.

Teitz T., Fang J., Goktug A. N., Bonga J. D., Diao S., Hazlitt R. A., Iconaru L., Morfouace M., Currier D., Zhou Y., Umans R. A., Taylor M. R., Cheng C., Min J., Freeman B., Peng J., Roussel M. F., Kriwacki R., Guy R. K., Chen T, Zuo J. (2018) CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. J Exp Med 215:1187-1203.

Umans, R. A. Henson, H. E., Mu, F., Parupalli, C., Ju, B., Peters, J. L., Lanham, K. A., Plavicki, J. S., and Taylor, M. R. (2017). CNS angiogenesis and barriergenesis occur simultaneously. Developmental Biology 425:101-108. (Cover art) Ju, B., Chen, W., Orr, B. A., Spitsbergen, J. M., Jia, S., Eden, C. J., Henson, H. E., Taylor, M. R. (2015) Oncogenic KRAS promotes malignant brain tumors in zebrafish. Molecular Cancer 14:18.

Eden, C. J., Ju, B., Murugesan, M., Phoenix, T., Nimmervoll, B., Tong, Y., Ellison, D. W., Lessman, C. A., Taylor, M. R.*, and Gilbertson, R. J.* (2015) Orthotopic models of pediatric brain tumors in zebrafish. Oncogene 34:1736-42. *Co-corresponding authors.

Henson, H. E., Parupalli, C., Ju, B., Taylor, M. R. (2014) Functional and genetic analysis of choroid plexus development in zebrafish. Frontiers in Neuroscience 8:364.

Wu,, G., Diaz, A. K., Paugh, B. S., Rankin, S. L., Ju, B., Li, Y., Zhu, X., Qu, C., Chen, X., Zhang, J., Easton, J., Edmonson, M., Ma, X., Lu, C., Nagahawatte, P., Hedlund, E., Rusch, M., Pounds, S., Lin, T., Onar-Thomas, A., Huether, R., Kriwacki, R., Parker, M., Gupta, P., Becksfort, J., Wei, L., Mulder, H. L., Boggs, K., Vadodaria, B., Yergeau, D., Russell, J. C., Ochoa, K., Fulton, R. S., Fulton, L. L., Jones, C., Boop, F. A., Broniscer, A., Wetmore, C., Gajjar, A., Ding, L., Mardis, E. R., Wilson, R. K., Taylor, M. R., Downing, J. R., Ellison, D. W., Zhang, J., and Baker, S. J. (2014) The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nature Genetics 46:444-50.

Ju, B., Chen, W., Spitsbergen, J. M., Lu, J., Vogel, P., Peters, J. L., Wang, Y. D., Henson, H. E., Jia, S., Parupalli, C., and Taylor, M. R. (2014) Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway. Oncogenesis 3:e96.

Jia, S., Muto, A., Orisme, W., Henson, H. E., Parupalli, C., Ju, B., Baier, H., and Taylor, M. R. (2014) Zebrafish Cacna1fa is required for cone photoreceptor function and synaptic ribbon formation. Human Molecular Genetics 23:2981-94.