Explore the latest groundbreaking research from the University of Wisconsin-Madison’s Genetics & Genomics Department. This collection highlights recent publications by both faculty and students, showcasing the department’s commitment to advancing scientific knowledge. Stay informed about new discoveries and emerging trends that continue to position UW-Madison at the forefront of genetics and genomics research.
Crouch AL, Monsey L, Rambeau M, Ramos C, Yracheta JM, Anderson MZ. Metagenomic discovery of microbial eukaryotes in stool microbiomes. mBio. 2024 Oct 16;15(10):e0206324. doi: 10.1128/mbio.02063-24. Epub 2024 Aug 29. PMID: 39207108; PMCID: PMC11481512.
Crowther TW, Rappuoli R, Corinaldesi C, Danovaro R, Donohue TJ, Huisman J, Stein LY, Timmis JK, Timmis K, Anderson MZ, Bakken LR, Baylis M, Behrenfeld MJ, Boyd PW, Brettell I, Cavicchioli R, Delavaux CS, Foreman CM, Jansson JK, Koskella B, Milligan-McClellan K, North JA, Peterson D, Pizza M, Ramos JL, Reay D, Remais JV, Rich VI, Ripple WJ, Singh BK, Smith GR, Stewart FJ, Sullivan MB, van den Hoogen J, van Oppen MJH, Webster NS, Zohner CM, van Galen LG. Scientists’ call to action: Microbes, planetary health, and the Sustainable Development Goals. Cell. 2024 Sep 19;187(19):5195-5216. doi: 10.1016/j.cell.2024.07.051. PMID: 39303686.
Dutcher HA, Gasch AP. Investigating the role of RNA-binding protein Ssd1 in aneuploidy tolerance through network analysis. RNA. 2024 Oct 29:rna.080199.124. doi: 10.1261/rna.080199.124. Epub ahead of print. PMID: 39471998.
Dutcher HA, Hose J, Howe H, Rojas J, Gasch AP. The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast. PLoS Genet. 2024 Oct 25;20(10):e1011454. doi: 10.1371/journal.pgen.1011454. PMID: 39453980; PMCID: PMC11540229.
Escalante LE, Hose J, Howe H, Paulsen N, Place M, Gasch AP. Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control. bioRxiv [Preprint]. 2024 Jun 23:2024.06.22.600216. doi: 10.1101/2024.06.22.600216. PMID: 38948718; PMCID: PMC11213126.
Hose J, Zhang Q, Sharp NP, Gasch AP. On the rate of aneuploidy reversion in a wild yeast model. Genetics. 2024 Nov 25:iyae196. doi: 10.1093/genetics/iyae196. Epub ahead of print. PMID: 39584496.
Kim SW, Lee H, Song DY, Lee GH, Ji J, Park JW, Han JH, Lee JW, Byun HJ, Son JH, Kim YR, Lee Y, Kim J, Jung A, Lee J, Kim E, Kim SH, Lee JH, Satterstrom FK, Girirajan S, Børglum AD, Grove J, Kim E, Werling DM, Yoo HJ, An JY. Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism. Genome Med. 2024 Sep 27;16(1):114. doi: 10.1186/s13073-024-01385-6. PMID: 39334436; PMCID: PMC11429951.
Kissel LT, Pochareddy S, An JY, Sestan N, Sanders SJ, Wang X, Werling DM. Sex-Differential Gene Expression in Developing Human Cortex and Its Intersection With Autism Risk Pathways. Biol Psychiatry Glob Open Sci. 2024 Apr 26;4(4):100321. doi: 10.1016/j.bpsgos.2024.100321. PMID: 38957312; PMCID: PMC11217612.
Kong S, Zhu M, Scarpin MR, Pan D, Jia L, Martinez RE, Alamos S, Vadde BVL, Garcia HG, Qian SB, Brunkard JO, Roeder AHK. DRMY1 promotes robust morphogenesis in Arabidopsis by sustaining the translation of cytokinin-signaling inhibitor proteins. Dev Cell. 2024 Dec 2;59(23):3141-3160.e7. doi: 10.1016/j.devcel.2024.08.010. Epub 2024 Sep 20. PMID: 39305905; PMCID: PMC11614703.
Melde RH, Abraham JM, Ugolini MR, Castle MP, Fjalstad MM, Blumstein DM, Durski SJ, Sharp NP. Sex-specific viability effects of mutations in Drosophila melanogaster. Evolution. 2024 Oct 28;78(11):1844-1853. doi: 10.1093/evolut/qpae134. PMID: 39277542.
Opulente DA, LaBella AL, Harrison MC, Wolters JF, Liu C, Li Y, Kominek J, Steenwyk JL, Stoneman HR, VanDenAvond J, Miller CR, Langdon QK, Silva M, Gonçalves C, Ubbelohde EJ, Li Y, Buh KV, Jarzyna M, Haase MAB, Rosa CA, ČCadež N, Libkind D, DeVirgilio JH, Hulfachor AB, Kurtzman CP, Sampaio JP, Gonçalves P, Zhou X, Shen XX, Groenewald M, Rokas A, Hittinger CT. Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts. Science. 2024 Apr 26;384(6694):eadj4503. doi: 10.1126/science.adj4503. Epub 2024 Apr 26. PMID: 38662846; PMCID: PMC11298794.
Patel SA, Park S, Zhu D, Torr EE, Dureke AG, McIntyre A, Muzyka N, Severson J, Skop AR. Extracellular vesicles, including large translating vesicles called midbody remnants, are released during the cell cycle. Mol Biol Cell. 2024 Dec 1;35(12):ar155. doi: 10.1091/mbc.E23-10-0384. Epub 2024 Nov 13. PMID: 39535882.
Rojas J, Hose J, Dutcher HA, Place M, Wolters JF, Hittinger CT, Gasch AP. Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast model. Cell Genom. 2024 Oct 9;4(10):100656. doi: 10.1016/j.xgen.2024.100656. Epub 2024 Sep 23. PMID: 39317188; PMCID: PMC11602619.
Szarzanowicz MJ, Waldburger LM, Busche M, Geiselman GM, Kirkpatrick LD, Kehl AJ, Tahmin C, Kuo RC, McCauley J, Pannu H, Cui R, Liu S, Hillson NJ, Brunkard JO, Keasling JD, Gladden JM, Thompson MG, Shih PM. Binary vector copy number engineering improves Agrobacterium-mediated transformation. Nat Biotechnol. 2024 Nov 4. doi: 10.1038/s41587-024-02462-2. Epub ahead of print. PMID: 39496930.