Explore the latest groundbreaking research from the University of Wisconsin-Madison’s Genetics & Genomics Department. This collection highlights recent publications by both faculty and students, showcasing the department’s commitment to advancing scientific knowledge. Stay informed about new discoveries and emerging trends that continue to position UW-Madison at the forefront of genetics and genomics research.
Kocik, R. A., Cytrynbaum, E. G., Ahrens, J. M., McClean, M. N., & Gasch, A. P. The importance of regulated resource reallocation during dynamic environmental shifts in yeast. The EMBO Journal. (March 2026). https://doi.org/10.1038/s44318-026-00727-x
Rodriguez-Parks, A., Beezley, E. G., Manna, S., Silaban, I., Almutawa, S. I., Cao, S., Ahmed, H., Guyer, M., Baker, S., Richards, M. P., & Kang, J. Advancing knock-in approaches for robust genome editing in zebrafish. Biology Open. (February 2026). https://doi.org/10.1242/bio.062472
Yun, G., Liu, R., & Sharp, N. P. Quantitative genetics of trauma induced mortality in Drosophila melanogaster. Heredity. (February 2026). https://doi.org/10.1038/s41437-026-00828-7
Sandell, L., Bazzicalupo, A. L., Otto, S. P., & Sharp, N. P. Evolutionary responses to increased opportunity for sexual selection in yeast. BMC Ecology and Evolution. (February 2026). https://doi.org/10.1186/s12862-026-02499-8
Melde, R., Daigle, A., Abraham, J., & Sharp, N. P. Meiotic double-strand DNA breaks and spontaneous mutation in Drosophila melanogaster. G3: Genes, Genomes, Genetics. (January 2026). https://doi.org/10.1093/g3journal/jkag019
Lee, H., Eynullazada, K., Ou, Q., Shin, J., Roy, S., & Engin, F. Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice. Nature Communications. (November 2025). https://doi.org/10.1038/s41467-025-65635-w
Patel, S. A., Park, S., Zhu, D., Torr, E. E., Dureke, A. G., McIntyre, A., Muzyka, N., Severson, J., & Skop, A. R. Extracellular vesicles, including large translating vesicles called midbody remnants, are released during the cell cycle. Molecular Biology of the Cell. (December 2024). https://doi.org/10.1091/mbc.E23-10-0384
Dutcher, H. A. & Gasch, A. P. Investigating the role of RNA-binding protein Ssd1 in aneuploidy tolerance through network analysis. RNA (New York). (December 2024). https://doi.org/10.1261/rna.080199.124
Kong, S., Zhu, M., Scarpin, M. R., Pan, D., Jia, L., Martinez, R. E., Alamos, S., Vadde, B. V. L., Garcia, H. G., Qian, S. B., Brunkard, J. O., & Roeder, A. H. K. DRMY1 promotes robust morphogenesis in Arabidopsis by sustaining the translation of cytokinin-signaling inhibitor proteins. Developmental Cell. (December 2024). https://doi.org/10.1016/j.devcel.2024.08.010
Szarzanowicz, M. J., Waldburger, L. M., Busche, M., Geiselman, G. M., Kirkpatrick, L. D., Kehl, A. J., Tahmin, C., Kuo, R. C., McCauley, J., Pannu, H., Cui, R., Liu, S., Hillson, N. J., Brunkard, J. O., Keasling, J. D., Gladden, J. M., Thompson, M. G,, & Shih, P. M. Binary vector copy number engineering improves Agrobacterium-mediated transformation. Nature Biotechnology. (November 2024). https://doi.org/10.1038/s41587-024-02462-2
Hose, J., Zhang, Q., Sharp, N. P., & Gasch, A. P. On the rate of aneuploidy reversion in a wild yeast model. Genetics. (November 2024). https://doi.org/10.1093/genetics/iyae196
Rojas, J., Hose, J., Dutcher, H. A., Place, M., Wolters, J. F., Hittinger, C. T., & Gasch, A. P. Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast model. bioRxiv: the preprint server for biology. (October 2024). https://doi.org/10.1101/2024.04.09.588778
Melde, R. H., Abraham, J. M., Ugolini, M. R., Castle, M. P., Fjalstad, M. M., Blumstein, D. M., Durski, S. J., & Sharp, N. P. Sex-specific viability effects of mutations in Drosophila melanogaster. Evolution: International Journal of Organic Evolution. (October 2024). https://doi.org/10.1093/evolut/qpae134
Dutcher, H. A., Hose, J., Howe, H., Rojas, J., & Gasch, A. P. The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast. PLOS Genetics. (October 2024). https://doi.org/10.1371/journal.pgen.1011454
Crouch, A. L., Monsey, L., Rambeau, M., Ramos, C., Yracheta, J. M., & Anderson, M. Z. Metagenomic discovery of microbial eukaryotes in stool microbiomes. mBio. (October 2024). https://doi.org/10.1128/mbio.02063-24
Crowther, T. W., Rappuoli, R., Corinaldesi, C., Danovaro, R., Donohue, T. J., Huisman, J., Stein, L. Y., Timmis, J. K., Timmis, K., Anderson, M. Z., Bakken, L. R., Baylis, M., Behrenfeld, M. J., Boyd, P. W., Brettell, I., Cavicchioli, R., Delavaux, C. S., Foreman, C. M., Jansson, J. K., Koskella, B., Milligan-McClellan, K., North, J. A., Peterson, D., Pizza, M., Ramos, J. L., Reay, D., Remais, J. V., Rich, V. I., Ripple, W. J., Singh, B. K., Smith, G. R., Stewart, F. J., Sullivan, M. B., van den Hoogen, J., van Oppen, M. J. H., Webster, N. S., Zohner, C. M., & van Galen, L. G. Scientists’ call to action: Microbes, planetary health, and the Sustainable Development Goals. Cell. (September 2024). https://doi.org/10.1016/j.cell.2024.07.051
Kim, S. W., Lee, H., Song, D. Y., Lee, G. H., Ji, J., Park, J. W., Han, J. H., Lee, J. W., Byun, H. J., Son, J. H., Kim, Y. R., Lee, Y., Kim, J., Jung, A., Lee, J., Kim, E., Kim, S. H., Lee, J. H., Satterstrom, F. K., Girirajan, S., Børglum, A. D., Grove, J., Kim, E., Werling, D. M., Yoo, H. J., & An, J. Y. Whole genome sequencing analysis identifies sex differences of familial pattern contributing to phenotypic diversity in autism. Genome Medicine. (September 2024). https://doi.org/10.1186/s13073-024-01385-6
Escalante, L. E., Hose, J., Howe, H., Paulsen, N., Place. M., & Gasch, A. P. Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control. bioRxiv: the preprint server for biology. (June 2024). https://doi.org/10.1101/2024.06.22.600216
Kissel, L. T., Pochareddy, S., An, J. Y., Sestan, N., Sanders, S. J., Wang, X., & Werling, D. M. Sex-Differential Gene Expression in Developing Human Cortex and Its Intersection With Autism Risk Pathways. Biological Psychiatry Global Open Science. (April 2024). https://doi.org/10.1016/j.bpsgos.2024.100321
Opulente, D. A., LaBella, A. L., Harrison, M. C., Wolters, J. F., Liu, C., Li, Y., Kominek, J., Steenwyk, J. L., Stoneman, H. R., VanDenAvond, J., Miller, C. R., Langdon, Q. K., Silva, M., Gonçalves, C., Ubbelohde, E. J., Li, Y., Buh, K. V., Jarzyna, M., Haase, M. A. B., Rosa, C. A., ČCadež, N., Libkind, D., DeVirgilio, J. H., Hulfachor, A. B., Kurtzman, C. P., Sampaio, J. P., Gonçalves, P., Zhou, X., Shen, X. X., Groenewald, M., Rokas, A., & Hittinger, C. T. Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts. Science (New York). (April 2024). https://doi.org/10.1126/science.adj4503