Disease Biology

Faculty studying disease biology

Caroline Alexander

Address:
Oncology
Metabolic physiology

Reid Alisch

Address:
Neurological Surgery
The role of epigenetics in human health and disease processes, particularly in relation to the origins of mental illness.

Alan Attie

Address:
Biochemistry
Genetics of type 2 diabetes and related metabolic diseases

Anjon Audhya

Address:
Biomolecular Chemistry
Regulation of vesicle biogenesis and membrane transport during development

Andrew Bent

Address:
Plant Pathology
Molecular/Genetic Mechanisms of Plant Disease Resistance

Barak Blum

Address:
Cell and Regenerative Biology
Regenerative biology of the endocrine pancreas, genetics of type-1 and type-2 diabetes

David Brow

Address:
Biomolecular Chemistry
Molecular mechanisms of transcription termination and pre-mRNA splicing in yeast

Hao Chang

Address:
Dermatology
Planar cell polarity in mammalian skin development and cancer

Qiang Chang

Address:
Medical Genetics and Neurology
DNA methylation-dependent epigenetic regulation of brain functions

Lara Collier

Address:
Pharmaceutical Sciences Division, School of Pharmacy
Genetic and pharmacological approaches in mouse models to study disease etiology and treatment

Kerri Coon

Address:
Bacteriology
Insect-microbe interactions, impacts of gut microbes on the biology of disease vectors

Katie Drerup

Address:
Integrative Biology
Neuronal Cell Biology, Neurodegenerative disease, Neurodevelopment

Feyza Engin

Address:
Biomolecular Chemistry
Diabetes and metabolic disorders, organelle dysfunction, stress responses, beta cell biology

Daniel S. Greenspan

Address:
Cell and Regenerative Biology
Genes important to vertebrate development and human disease

Melissa Harrison

Address:
Biomolecular Chemistry
Transcriptional regulation during development

Aaron Hoskins

Address:
Biochemistry
RNA splicing, gene expression, fluorescence microscopy, RNA/protein complexes

Zhen Huang

Address:
Neurology and Nueroscience
Neuron and glial cell fate specification and differentiation, cortical neuron migration, migration disorders

Christina Hull

Address:
Biomolecular Chemistry and Medical Microbiology & Immunology
The goal of the Hull Laboratory is to understand how eukaryotic pathogen development and differentiation intersect with human disease. We take a hypothesis-driven experimental approach to discover the molecular mechanisms by which the model pathogenic fungus Cryptococcus reproduces and ultimately causes fatal meningitis. Students and post-docs in the lab are encouraged to work across disciplines to explore diverse aspects of biology to solve meaningful and challenging problems in biomedicine.

Anna Huttenlocher

Address:
Pediatrics
Cell migration, Wound repair, Inflammation

Akihiro Ikeda

Address:
Medical Genetics
Identifying genes involved in aging, cell proliferation and neovascularization using mouse genetics

Nancy Keller

Address:
Medical Microbiology and Immunology
Fungal genetics, fungal/bacterial interactions, mining fungal genomes for bioactive chemicals

Judith Kimble

Address:
Biochemistry, Molecular Biology and Medical Genetics
Molecular regulation of germ line self-renewal and differentiation in C. elegans

Peter Lewis

Address:
Biomolecular Chemistry
Mechanisms of chromatin assembly, gene silencing, and epigenetic inheritance

Valentina Lo Sardo

Address:
Cellular and Molecular Biology
Stem cell biology, reprogramming, cell fate determination, genetic risk factors for Cardiovascular disease and Cancer, genomics, transcriptomics, human specific genomic regions, evolution

Ahmed Mahmoud

Address:
Cell and Regenerative Biology
Mammalian cardiac regeneration

Brian Parks

Address:
Nutritional Sciences
Leveraging genetics to understand the pathways and molecular mechanisms that contribute to metabolic diseases.

Nicole Perna

Address:
Genetics
Systems-scale evolutionary genomics of agriculturally, biomedically and industrially significant bacteria

Jason Peters

Address:
Pharmaceutical Sciences
Gene networks and genetic tools in bacteria.

Vatsan Raman

Address:
Biochemistry
High-throughput functional assays, variant effect prediction, human and microbial genomics

Steven Schrodi

Address:
Medical Genetics
Human genomics of inflammatory diseases, statistical genetics, genetic architecture of diseases

David Schwartz

Address:
Genetics and Chemistry
Discovery of fundamental molecular phenomena, which are harnessed within fully integrated systems for comprehensive genome analysis; creation of a cell-free system (“GenSyn”) for the direct fabrication of synthetic chromosomes, which adapt/advance micro- and nanofluidics technologies previously developed for genome analysis by the Schwartz group

Ahna Skop

Address:
Genetics, Medical Genetics and Life Science Communications
Asymmetric cell division, cytokinesis, cell polarity & cell cycle genomics and proteomics

Paul Sondel

Address:
Pediatrics and Human Oncology
Antibody recognition of cancer cells in mice and in patients

Michael Taylor

Address:
School of Pharmacy, Pharmaceutical Sciences Division
Regulation of CNS angiogenesis and barriergenesis

Randal Tibbetts

Address:
Human Oncology
Genetic control of DNA replication and repair in mammals. Mechanisms of neurodegeneration in amyotrophic lateral sclerosis (ALS)

Daifeng Wang

Address:
Biostatistics and Medical Informatics
Gene regulatory networks, functional genomics, genotype-phenotype prediction, single-cell biology, brain disorders

David Wassarman

Address:
Mechanisms underlying neurodegeneration

Beth A. Weaver

Address:
Cell and Regenerative Biology; Oncology/McArdle Laboratory for Cancer Research
Mitosis, Aneuploidy, Chromosomal instability, Cancer

Donna Werling

Address:
Genetics
Genetic risk for autism and other neuropsychiatric conditions, sex differences in neurobiology and risk for disease

Jerry Yin

Address:
Medical Genetics and Neurology
cAMP/PKA/dCREB2 signaling in sleep, memory formation, neurodegenerative diseases, developmental disabilities

Jing Zhang

Address:
McArdle Laboratory for Cancer Research
Cell signaling in hematopoiesis and leukemogenesis