Alan Attie
Position title: Professor
Email: adattie@wisc.edu
Phone: 608-262-1372
Address:
Biochemistry
Genetics & Genomics of Metabolic Disease and Response to Diet
- Address
- 543A Biochemistry
- Lab website
- https://biochem.wisc.edu/people/attie/
- Education
- Ph.D., University of California-San Diego, 1980, Postdoctoral Research: University of California-San Deigo, Department of Medicine
- Department
- Biochemistry
- Research Interest
- Genetics & Genomics of Metabolic Disease and Response to Diet
- Research Fields
- Disease Biology, Cell Biology, Computational, Systems & Synthetic Biology, Gene Expression, Genomics & Proteomics, Human, mouse & rat
Research Description:
Genetic Pipeline
Our projects come from genes we identify in our screens using mouse genetics. We study these genes in transgenic mice and in cell lines. We have discovered many novel genes involved in diabetes susceptibility and lipid metabolism.
Genetics of metabolic outcome
There is tremendous variability in the response of individuals to different diets. Likewise, mouse strains vary in their response to diet. These responses are due to differences in the control of metabolic pathways. We are conducting a genetic screen using stable isotope tracers to measure metabolic outcome through many pathways in mice subjected to two extreme diets. We will map the genetic drivers responsible for strain differences in diet responsiveness
Representative Publications:
Search PubMed for more publications by Alan Attie
Price, T. R., D. S. Stapleton, K. L. Schueler, M. K. Norris, B. W. Parks, B. S. Yandell, G. A. Churchill, W. L. Holland, M. P. Keller, and A. D. Attie. 2023. Lipidomic QTL in Diversity Outbred mice identifies a novel function for α/β hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin. PLoS Genet 19: e1010713.
de Klerk, E., Y. Xiao, C. H. Emfinger, M. P. Keller, D. I. Berrios, V. Loconte, A. A. Ekman, K. L. White, R. L. Cardone, R. G. Kibbey, A. D. Attie, and M. Hebrok. 2023. Loss of ZNF148 enhances insulin secretion in human pancreatic β cells. JCI Insight 8.
Emfinger, C. H., E. de Klerk, K. L. Schueler, M. E. Rabaglia, D. S. Stapleton, S. P. Simonett, K. A. Mitok, Z. Wang, X. Liu, J. A. Paulo, Q. Yu, R. L. Cardone, H. R. Foster, S. L. Lewandowski, J. C. Perales, C. M. Kendziorski, S. P. Gygi, R. G. Kibbey, M. P. Keller, M. Hebrok, M. J. Merrins, and A. D. Attie. 2022. β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses. JCI Insight 7.
Simonett, S. P., S. Shin, J. A. Herring, R. Bacher, L. A. Smith, C. Dong, M. E. Rabaglia, D. S. Stapleton, K. L. Schueler, J. Choi, M. N. Bernstein, D. R. Turkewitz, C. Perez-Cervantes, J. Spaeth, R. Stein, J. S. Tessem, C. Kendziorski, S. Keleş, I. P. Moskowitz, M. P. Keller, and A. D. Attie. 2021. Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation. J Clin Invest 131.