Position title: Assistant Professor
Metabolism - Adipose Tissue physiology - Obesity - Type 2 Diabetes - Cachexia
- Ph.D. University of Milan, Postdoctoral Research The Scripps Research Institute
- Research Fields
- Cell Biology, Gene Expression, Genomics and Proteomics
My group is interested in understanding the molecular mechanisms that control metabolic adaptation in response to environmental stimuli and in pathophysiological conditions. We are specifically focused on obesity and the role of adipose tissue dysfunction during the progression of obesity and insulin resistance. Adipocyte dysfunction is central to the onset of obesity-associated type 2 diabetes and agents that can restore proper adipocyte function have often shown therapeutic effects in vivo. By integrating chemical proteomics, cellular and biochemical assays, and in-depth mouse phenotyping, we intend to identify novel functional pathways in adipocytes amenable to pharmacological modulation that can provide new avenues to treat obesity and obesity-linked metabolic disorders.
Galmozzi A, Kok BP, Kim AS, Montenegro-Burke JR, Lee JY, Spreafico R, Mosure S, Albert V, Cintron-Colon R, Godio C, Webb WR, Conti B, Solt LA, Kojetin D, Parker CG, Peluso JJ, Pru JK, Siuzdak G, Cravatt BF, Saez E. PGRMC2 is an intracellular haem chaperone critical for adipocyte function. Nature. 2019 Dec;576(7785):138-142. doi: 10.1038/s41586-019-1774-2. Epub 2019 Nov 20. PubMed PMID: 31748741; PubMed Central PMCID: PMC6895438.
Parker CG, Galmozzi A, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF. Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19. PubMed PMID: 28111073; PubMed Central PMCID: PMC5632530.
Galmozzi A, Kok BP, Saez E. Isolation and Differentiation of Primary White and Brown Preadipocytes from Newborn Mice. J Vis Exp. 2021 Jan 25;(167). doi: 10.3791/62005. PubMed PMID: 33554974; PubMed Central PMCID: PMC8009622.