Audrey Gasch

Position title: Professor

Email: agasch@wisc.edu

Phone: 608-265-0859

Address:
Medical Genetics
Elucidating the role, regulation, and evolution of eukaryotic stress responses

Address
4426 Genetics-Biotech
Education
Ph.D. (2000) Stanford University, Postdoctoral Research: Lawrence Berkeley National Laboratory/University of California, Berkeley, 2000-2003
Lab Website
http://gasch.genetics.wisc.edu/
Department
Genetics
Research Interests
Elucidating the role, regulation, and evolution of eukaryotic stress responses.
Research Fields
Computational, Systems & Synthetic Biology, Evolutionary & Population Genetics, Gene Expression, Genomics & Proteomics, Fungi

Research Description:
All organisms must be able to sense and respond to their environment and defend themselves against environmental stress. Cells respond to acute environmental stress by mounting a multi-faceted cellular response that typically includes coordinated changes in transcription and translation, protein function, and metabolic fluxes, along with transient arrest of growth and cell cycle progression. How these disparate physiological processes are coordinated is poorly understood but likely critical for surviving and acclimating to stressful conditions.

The Gasch Lab uses modern techniques in comparative and functional genomics, computational and systems biology, and genetics and molecular biology to study how cells sense their environment, detect when there is a problem, and then coordinate a multi-faceted response to protect themselves. We study these topics in the budding yeast Saccharomyces cerevisiae as a model for basic biology. Because defects in sensing and responding to cellular stress are linked to many human diseases, and because much of yeast physiology is similar to human cells, our research is generating important insights into how normal cells function and when problems cause disease.

We are also interested in the relationship between genotype and phenotype and the interplay with the environment. We study these questions at a mechanistic level in wild isolates of budding yeast, and at the computational level across eukaryotes including humans. We are part of several collaborative efforts leveraging model-organism genetics to inform on human genetic variation and disease susceptibility.


Representative Publications:
Search PubMed for more publications by Audrey Gasch

Escalante LE, Hose J, Howe H, Paulsen N, Place M, Gasch AP. Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control. bioRxiv [Preprint]. 2024 Jun 23:2024.06.22.600216. doi: 10.1101/2024.06.22.600216. PMID: 38948718; PMCID: PMC11213126.

Rojas J, Hose J, Auguste Dutcher H, Place M, Wolters JF, Hittinger CT, Gasch AP. Comparative modeling reveals the molecular determinants of aneuploidy fitness cost in a wild yeast model. bioRxiv [Preprint]. 2024 Apr 13:2024.04.09.588778. doi: 10.1101/2024.04.09.588778. PMID: 38645209; PMCID: PMC11030387.

Robinson D, Place M, Hose J, Jochem A, Gasch AP. Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories. Elife. 2021 Aug 2;10:e70564. doi: 10.7554/eLife.70564. PMID: 34338637; PMCID: PMC8352584.

Hose J, Escalante LE, Clowers KJ, Dutcher HA, Robinson D, Bouriakov V, Coon JJ, Shishkova E, Gasch AP. The genetic basis of aneuploidy tolerance in wild yeast. Elife. 2020 Jan 7;9:e52063. doi: 10.7554/eLife.52063. PMID: 31909711; PMCID: PMC6970514.

MacGilvray ME, Shishkova E, Place M, Wagner ER, Coon JJ, Gasch AP. Phosphoproteome Response to Dithiothreitol Reveals Unique Versus Shared Features of Saccharomyces cerevisiae Stress Responses. J Proteome Res. 2020 Aug 7;19(8):3405-3417. doi: 10.1021/acs.jproteome.0c00253. Epub 2020 Jul 13. PMID: 32597660; PMCID: PMC7646510.

Ho YH, Shishkova E, Hose J, Coon JJ, Gasch AP. Decoupling Yeast Cell Division and Stress Defense Implicates mRNA Repression in Translational Reallocation during Stress. Curr Biol. 2018 Aug 20;28(16):2673-2680.e4. doi: 10.1016/j.cub.2018.06.044. Epub 2018 Aug 2. PMID: 30078561; PMCID: PMC6132260.

MacGilvray ME, Shishkova E, Chasman D, Place M, Gitter A, Coon JJ, Gasch AP. Network inference reveals novel connections in pathways regulating growth and defense in the yeast salt response. PLoS Comput Biol. 2018 May 8;13(5):e1006088. doi: 10.1371/journal.pcbi.1006088. PMID: 29738528; PMCID: PMC5940180.

Chasman D, Ho YH, Berry DB, Nemec CM, MacGilvray ME, Hose J, Merrill AE, Lee MV, Will JL, Coon JJ, Ansari AZ, Craven M, Gasch AP. Pathway connectivity and signaling coordination in the yeast stress-activated signaling network. Mol Syst Biol. 2014 Nov 19;10(11):759. doi: 10.15252/msb.20145120. PMID: 25411400; PMCID: PMC4299600.