Jeff Hardin

Position title: Professor

Phone: 608-262-9634

Address:
Integrative Biology
Cell movement, cell adhesion, embryonic development

Address: 327 Integrative Biology Research
Website: https://worms.zoology.wisc.edu
Education: Ph.D., University of California, Berkeley (1987), Postdoctoral Research: Duke University
Department: Integrative Biology
Research Interests: Cell movement, cell adhesion, embryonic development
Research Fields: Cell Biology, Development, Gene expression, C. elegans

Research Description:
We use the C. elegans embryo as a model for investigating cell movement and cell adhesion during embryonic development; understanding how cells move, and how they make and break adhesions has important implications for understanding birth defects during human development and for understanding cancer progression.

Representative Publications:
Search PubMed for more publications by Jeff Hardin

Choi, H.-J.*, Loveless, T.*, Lynch, A.M., Bang, I., Hardin, J+, and Weis, W.I.+. A conserved phosphorylation switch controls the interaction between cadherin and β-catenin In vitro and In vivo. Developmental Cell 33, 82–93. [*Co-first authors; +Co-senior authors]

Walck-Shannon, E. and Hardin, J. (2014). Cell intercalation from top to bottom. Nature Rev. Mol. Cell. Bio 15:34-48.

Maiden, S.L., Harrison, N., Keegan, J., Cain, B., Lynch, A.M., Pettitt, J., and Hardin, J. (2013). Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/α-catenin modulate F-actin binding independently of vinculin. J. Biol. Chem. 288:5694-5706.

Lynch, A.M., Grana, T., Cox-Paulson, E., Couthier, A., Cameron, M., Chin-Sang, I., Pettitt, J., and Hardin, J. (2012). A genome-wide functional screen identifies MAGI-1 as an L1CAM-dependent stabilizer of apical junctions in C. elegans. Curr. Biol. 22, 1891–1899.

Cox-Paulson, E., Walck-Shannon, E., Lynch, A., Yamashiro, S., Zaidel-Bar, R., Celeste C. Eno, C., Ono, S., and Hardin, J. (2012). Tropomodulin protects α-catenin-dependent junctional actin networks under stress during epithelial morphogenesis. Curr. Biol. 22:1500-1505.

Ikegami, R., Simokat, K., Zheng, H., Dixon, L., Garriga, G., Hardin, J. and Culotti, J. (2012). Semaphorin and Eph receptor signaling guide a series of cell movements for ventral enclosure in C. elegans. Curr. Biol. 22:1–11.

Loveless, T. and Hardin, J. (2012). Cadherin complexity: recent insights into cadherin superfamily function in C. elegans. Curr. Opin. Cell Biol. 24:695-701.

Zaidel-Bar, R., Joyce, M.J., Lynch, A.M., Witte, K., Audhya, A., and Hardin, J. (2010). The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis. J. Cell Biol. 191, 761-9.

Kwiatkowski, A.V., Maiden, S.L., Pokutta, S., Choi, H.-J., Benjamin, J.M., Lynch, A.M., Nelson, W.J., Weis, W.I., and Hardin, J. (2010). In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. PNAS 107:14591-14596.

Grana, T.M., Cox, E.A., Lynch, A.M., and Hardin, J. (2010). SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation. Dev. Biol. 344:731–744.