Jeff Hardin

Position title: Professor

Email: jdhardin@wisc.edu

Phone: 608-262-9634

Address:
Integrative Biology
We use the C. elegans embryo as a model for investigating cell movement and cell adhesion during embryonic development; understanding how cells move, and how they make and break adhesions has important implications for understanding birth defects during human development and for understanding cancer progression.

Address
327 Integrative Biology Research
Website
https://worms.zoology.wisc.edu
Education
Ph.D., University of California, Berkeley (1987), Postdoctoral Research: Duke University
Department
Integrative Biology
Research Interests
We use the C. elegans embryo as a model for investigating cell movement and cell adhesion during embryonic development; understanding how cells move, and how they make and break adhesions has important implications for understanding birth defects during human development and for understanding cancer progression.
Research Fields
Cell Biology, Development, C. elegans

Research Description:
We use the C. elegans embryo as a model for investigating cell movement and cell adhesion during embryonic development; understanding how cells move, and how they make and break adhesions has important implications for understanding birth defects during human development and for understanding cancer progression.


Representative Publications:
Search PubMed for more publications by Jeff Hardin

Choi, H.-J.*, Loveless, T.*, Lynch, A.M., Bang, I., Hardin, J+, and Weis, W.I.+. A conserved phosphorylation switch controls the interaction between cadherin and β-catenin In vitro and In vivo. Developmental Cell 33, 82–93. [*Co-first authors; +Co-senior authors]

Walck-Shannon, E. and Hardin, J. (2014). Cell intercalation from top to bottom. Nature Rev. Mol. Cell. Bio 15:34-48.

Maiden, S.L., Harrison, N., Keegan, J., Cain, B., Lynch, A.M., Pettitt, J., and Hardin, J. (2013). Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/α-catenin modulate F-actin binding independently of vinculin. J. Biol. Chem. 288:5694-5706.

Lynch, A.M., Grana, T., Cox-Paulson, E., Couthier, A., Cameron, M., Chin-Sang, I., Pettitt, J., and Hardin, J. (2012). A genome-wide functional screen identifies MAGI-1 as an L1CAM-dependent stabilizer of apical junctions in C. elegans. Curr. Biol. 22, 1891–1899.

Cox-Paulson, E., Walck-Shannon, E., Lynch, A., Yamashiro, S., Zaidel-Bar, R., Celeste C. Eno, C., Ono, S., and Hardin, J. (2012). Tropomodulin protects α-catenin-dependent junctional actin networks under stress during epithelial morphogenesis. Curr. Biol. 22:1500-1505.

Ikegami, R., Simokat, K., Zheng, H., Dixon, L., Garriga, G., Hardin, J. and Culotti, J. (2012). Semaphorin and Eph receptor signaling guide a series of cell movements for ventral enclosure in C. elegans. Curr. Biol. 22:1–11.

Loveless, T. and Hardin, J. (2012). Cadherin complexity: recent insights into cadherin superfamily function in C. elegans. Curr. Opin. Cell Biol. 24:695-701.

Zaidel-Bar, R., Joyce, M.J., Lynch, A.M., Witte, K., Audhya, A., and Hardin, J. (2010). The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis. J. Cell Biol. 191, 761-9.

Kwiatkowski, A.V., Maiden, S.L., Pokutta, S., Choi, H.-J., Benjamin, J.M., Lynch, A.M., Nelson, W.J., Weis, W.I., and Hardin, J. (2010). In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans. PNAS 107:14591-14596.

Grana, T.M., Cox, E.A., Lynch, A.M., and Hardin, J. (2010). SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation. Dev. Biol. 344:731–744.