Colleen Hayes

Position title: Professor

Phone: 608-263-6387

Address:
Biochemistry and Medical Microbiology
Genetic and biochemical studies of peripheral B lymphocyte development

Address: 5507 Biochemistry
Education: Ph.D., University of Michigan (1973), Postdoctoral Research: Harvard Medical School and University of Wisconsin- Madison
Department: Biochemistry and Medical Microbiology
Research Interests: Genetic and biochemical studies of peripheral B lymphocyte development
Research Fields: Gene Expression, Human and Mammalian, Mouse Genetics

Research Description:
Our laboratory studies B lymphocyte development. We discovered a B cell-intrinsic locus, Bcmd-1 (B cell maturation defect), that regulates the peripheral B lymphocyte life span. When Bcmd-1 is mutated, peripheral B lymphocytes die prematurely, rendering the animal profoundly B cell deficient and incapable of producing memory antibody responses. Current genetic experiments are mapping Bcmd-1 and constructing a congenic strain for future in vivo studies of Bcmd-1 function. A candidate locus is under investigation. Current biochemical experiments are testing growth factor receptor signal transduction pathways and the synthesis of apoptosis inhibitory proteins in wild-type and Bcmd-1-mutant B cells, with the goal of identifying the biochemical pathway that is disrupted by the Bcmd-1 mutation.

Representative Publications:
Search PubMed for more publications by Colleen Hayes

Steckley, J., D. Dyment, D. Sadovnick, N. Risch, C. Hayes, G. Ebers, and the Canadian Collaborative Study Group. 2000. Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients. Neurology, 54:729-732.

Nashold, F.E., D.J. Miller, and C.E. Hayes. 2000. 1,25-Dihydroxyvitamin D3 decreases macrophage accumulation in the CNS of mice with experimental autoimmune encephalomyelitis. J. Neuroimmunology 103:171-179.

Lentz, V. M., C. E. Hayes and M. P. Cancro. 1998. Bcmd decreases the lifespan of B-2 but not B-1 cells in A/WySnJ mice. J. Immunol. 160:3743-3747.

Cancro, M. P., D. M. Allman, C. E. Hayes, V. M. Lentz, R. G. Fields, and M. Tomayko. 1998. B cell maturation and selection at the marrow-periphery interface. Immunological Res. 17:3-11.