David Hershey

Position title: Assistant Professor

Email: dhershey@wisc.edu

Mechanisms of surface colonizatoin in bacteria, mechanosensing, extracellular matrix biosynthesis

PhD in Microbiology at the University of California - Berkeley; Postdoctoral fellow at the University of Chicago
Research Interests
Mechanisms of surface colonizatoin in bacteria, mechanosensing, extracellular matrix biosynthesis
Research Fields
Cell Biology, Computational, Systems and Synthetic Biology, Development, Bacteria and Other Microbes

Research Description:
Our laboratory studies how bacteria associate with other objects in their environments. The process of seeking, recognizing and growing on exogenous surfaces is fundamental to how bacteria associate with human tissues, and these behaviors have a profound impact on health. We use genetics, biochemistry and cell biology to characterize:

-How bacteria recognize physical contact

-How bacterial cells are reorganized in response to surface contact

-How complex polysaccharides are assembled

Understanding the strategies bacteria use to grow on surfaces will lead to novel interventions for managing microbial populations in clinical, industrial and agricultural settings.

Representative Publications:
Search PubMed for more publications by David Hershey

Hershey DM. Integrated control of surface adaptation by the bacterial flagellum. Curr Opin Microbiol. 2021 Feb 25;61:1-7. doi: 10.1016/j.mib.2021.02.004.

Hershey DM, Fiebig A, Crosson S. Flagellar Perturbations Activate Adhesion through Two Distinct Pathways in Caulobacter crescentus. mBio. 2021 Feb 9;12(1):e03266-20. doi: 10.1128/mBio.03266-20.

Urtecho G, Campbell DE, Hershey DM, Hussain FA, Whitaker RJ, O’Toole GA. Discovering the Molecular Determinants of Phaeobacter inhibens Susceptibility to Phaeobacter Phage MD18. mSphere. 2020 Nov 4;5(6):e00898-20. doi: 10.1128/mSphere.00898-20.

Hershey DM, Porfírio S, Black I, Jaehrig B, Heiss C, Azadi P, Fiebig A, Crosson S. Composition of the Holdfast Polysaccharide from Caulobacter crescentus. J Bacteriol. 2019 Aug 8;201(17):e00276-19. doi: 10.1128/JB.00276-19.

Hershey DM, Fiebig A, Crosson S. A Genome-Wide Analysis of Adhesion in Caulobacter crescentus Identifies New Regulatory and Biosynthetic Components for Holdfast Assembly. mBio. 2019 Feb 12;10(1):e02273-18. doi: 10.1128/mBio.02273-18.

Hershey DM, Browne PJ, Iavarone AT, Teyra J, Lee EH, Sidhu SS, Komeili A. Magnetite Biomineralization in Magnetospirillum magneticum Is Regulated by a Switch-like Behavior in the HtrA Protease MamE. J Biol Chem. 2016 Aug 19;291(34):17941-52. doi: 10.1074/jbc.M116.731000.

Hershey DM, Ren X, Melnyk RA, Browne PJ, Ozyamak E, Jones SR, Chang MC, Hurley JH, Komeili A. MamO Is a Repurposed Serine Protease that Promotes Magnetite Biomineralization through Direct Transition Metal Binding in Magnetotactic Bacteria. PLoS Biol. 2016 Mar 16;14(3):e1002402. doi: 10.1371/journal.pbio.1002402.

Lu X, Hershey DM, Wang L, Bogdanove AJ, Peters RJ. An ent-kaurene-derived diterpenoid virulence factor from Xanthomonas oryzae pv. oryzicola. New Phytol. 2015 Apr;206(1):295-302. doi: 10.1111/nph.13187. Hershey DM, Lu X, Zi J, Peters RJ. Functional conservation of the capacity for ent-kaurene biosynthesis and an associated operon in certain rhizobia. J Bacteriol. 2014 Jan;196(1):100-6. doi: 10.1128/JB.01031-13.