University of Wisconsin–Madison
College of Agriculture and Life Sciences | School of Medicine and Public Health

Zhen Huang

Associate Professor

z.huang@neurology.wisc.edu

608-263-2469

Neurology and Nueroscience
Neuron and glial cell fate specification and differentiation, cortical neuron migration, migration disorders

Address
1111 Highland Avenue, 5453 WIMR II
Education
Ph.D., Harvard University (1999), Postdoctoral Research: University of California San Francisco
Lab Website
http://neuro.wisc.edu/faculty/zhuang.asp
Department
Neurology and Nueroscience
Research Interests
Neural stem cell regulation of brain vessel development Neuron and glial cell fate specification Cortical neuron migration, layer formation, and neuronal differentiation Heterotrimeric G protein signaling Germinal matrix hemorrhage Neuronal migration disorders
Research Fields
Brain vessel development Neuron and glial cell fate specification Germinal matrix hemorrhage Neuronal migration disorders

Research Description:
We study how cell-cell signaling coordinate neural as well as vascular development in the brain and how these pathways may be harnessed for prevention and/or treatment of brain diseases


Representative Publications:
Ma, S., Kwon, H. J., Johng, H, Zang, K, and, Huang, Z. (2013). Radial glia neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biology 11(1): e1001469. doi:10.1371/journal.pbio.1001469

Ma, S., Kwon, H.J., Huang, Z. (2012). A functional requirement for astroglia in promoting blood vessel development in the early postnatal brain. PLoS One 7(10): e48001. doi:10.1371/journal.pone.0048001

Ma, S., Kwon, H.J., Huang, Z. (2012). Ric-8a, a guanine nucleotide exchange factor in GPCR signaling, regulates Bergmann glia-basement membrane adhesion during cerebellar foliation. The Journal of Neuroscience 32 (43): 14979 –14993.

Kwon, H.J., Ma, S., and Huang, Z. (2011) Radial glia regulate Cajla-Retzius cell positioning in the early embryonic cerebral cortex. Developmental Biology 351: 25-34. [Epub ahead of print] 2010 Dec 23.

Huang, Z. (2009) Molecular regulation of neuronal migration during neocortical development. Molecular Cellular Neuroscience 42(1):11-22. Epub 2009 Jun 10.

Huang, Z, Shimazu, K., Woo, N.H., Zang, K., Müller, U., Lu, B., and Reichardt, L.F. (2006). Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. The Journal of Neuroscience 26 (43): 11208-11219.

Huang, Z., Zang, K., and Reichardt, L.F. (2005). The origin recognition core complex regulates dendrite and dendritic spine development in postmitotic neurons. The Journal of Cell Biology 170 (4): 527-535.

Graus-Porta, D., Blaess, S., Senften, M., Littlewood-Evans, A., Damsky, C., Huang, Z., Orban, P., Klein, R., Schittny, J.C., and Müller, U. (2001). Beta 1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31(3): 367-79.

Huang, Z., Shilo, B-Z., and Kunes, S. (1998). A retinal axon fascicle uses Spitz, an EGF receptor ligand, to construct a synaptic cartridge in the brain of Drosophila. Cell 95 (5): 693–703.

Huang, Z. and Kunes, S. (1998). Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly. Development 125 (19), 3753-3764.

Huang, Z. and Kunes, S. (1996). Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain. Cell 86 (3): 411-422.