University of Wisconsin–Madison
College of Agriculture and Life Sciences | School of Medicine and Public Health

Zhen Huang

Associate Professor

z.huang@neurology.wisc.edu

608-263-2469

1111 Highland Avenue, 5453 WIMR II

Education
Ph.D., Harvard University (1999), Postdoctoral Research: University of California San Francisco
Lab Website
http://neuro.wisc.edu/faculty/zhuang.asp
Department
Neurology and Nueroscience
Research Interests
Neural stem cell regulation of brain vessel development Neuron and glial cell fate specification Cortical neuron migration, layer formation, and neuronal differentiation Heterotrimeric G protein signaling Germinal matrix hemorrhage Neuronal migration disorders
Research Fields
Brain vessel development Neuron and glial cell fate specification Germinal matrix hemorrhage Neuronal migration disorders

Research Description:
We study how cell-cell signaling coordinate neural as well as vascular development in the brain and how these pathways may be harnessed for prevention and/or treatment of brain diseases


Representative Publications:
Ma, S., Kwon, H. J., Johng, H, Zang, K, and, Huang, Z. (2013). Radial glia neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biology 11(1): e1001469. doi:10.1371/journal.pbio.1001469

Ma, S., Kwon, H.J., Huang, Z. (2012). A functional requirement for astroglia in promoting blood vessel development in the early postnatal brain. PLoS One 7(10): e48001. doi:10.1371/journal.pone.0048001

Ma, S., Kwon, H.J., Huang, Z. (2012). Ric-8a, a guanine nucleotide exchange factor in GPCR signaling, regulates Bergmann glia-basement membrane adhesion during cerebellar foliation. The Journal of Neuroscience 32 (43): 14979 –14993.

Kwon, H.J., Ma, S., and Huang, Z. (2011) Radial glia regulate Cajla-Retzius cell positioning in the early embryonic cerebral cortex. Developmental Biology 351: 25-34. [Epub ahead of print] 2010 Dec 23.

Huang, Z. (2009) Molecular regulation of neuronal migration during neocortical development. Molecular Cellular Neuroscience 42(1):11-22. Epub 2009 Jun 10.

Huang, Z, Shimazu, K., Woo, N.H., Zang, K., Müller, U., Lu, B., and Reichardt, L.F. (2006). Distinct roles of the beta 1-class integrins at the developing and the mature hippocampal excitatory synapse. The Journal of Neuroscience 26 (43): 11208-11219.

Huang, Z., Zang, K., and Reichardt, L.F. (2005). The origin recognition core complex regulates dendrite and dendritic spine development in postmitotic neurons. The Journal of Cell Biology 170 (4): 527-535.

Graus-Porta, D., Blaess, S., Senften, M., Littlewood-Evans, A., Damsky, C., Huang, Z., Orban, P., Klein, R., Schittny, J.C., and Müller, U. (2001). Beta 1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron 31(3): 367-79.

Huang, Z., Shilo, B-Z., and Kunes, S. (1998). A retinal axon fascicle uses Spitz, an EGF receptor ligand, to construct a synaptic cartridge in the brain of Drosophila. Cell 95 (5): 693–703.

Huang, Z. and Kunes, S. (1998). Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly. Development 125 (19), 3753-3764.

Huang, Z. and Kunes, S. (1996). Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain. Cell 86 (3): 411-422.