Junsu Kang

Our lab studies how zebrafish possess a remarkable potential to regenerate tissues, such as amputated appendages and damaged heart muscle. Our research topics include 1) Transcriptional regulation controlling heart regeneration, 2) il11-mediated heart repair, 3) Peripheral nervous systems (PNS) and fin regeneration, and 4) Discovery novel regenerative genes using forward genetic screening.

Representative Publications:

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Keating, M.*, Hagle, R.*, Osorio-Méndez, D.*, Rodriguez-Parks, A., Alutawa, S.I., Kang, J., A highly efficient knock-in approach using a minimal promoter and a minicircle. Developmental Biology, 2024 Jan:505:24-33. (2024) *: co-first authors

Shin, K., Begeman, I. J., Cao, J., Kang, J., leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Dev. Dyn. doi: 10.1002/dvdy.556. (2022)

Begeman, I.J., Emery, B., Kurth., A., Kang, J., Regeneration and Developmental Enhancers Are Differentially Compatible with Minimal Promoters. Dev. Biol. doi: 10.1016/j.ydbio.2022.09.007. (2022)

Osorio-Méndez, D., Miller, A., Begeman, I., Kurth, A., Hagle, R., Rolph, D., Dickson, A.L., Chen, C.H., Halloran, M., Poss, K.*, Kang, J.*, Voltage-gated sodium channel, scn8a, is required for innervation and regeneration of amputated adult zebrafish fins. (*Co-corresponding authors). Proc. Natl. Acad. Sci. USA. 119(28):e2200342119. (2022)

Begeman, I., Shin, K., Kurth, A., Lee, N., Chamberlain, T.J., Pelegri, F.J. and Kang, J. Decoding an organ regeneration switch by dissecting cardiac regeneration enhancers., Development. 147(24):dev1940192020, (2020).

Kang, J., Hu, J., Karra, R., Dickson, A.L, Tornini, V.A., Nachtrab, G., Gemberling, M., Goldman, J.A., Black, B.L., Poss, K.D. Modulation of tissue repair by regeneration enhancer elements. Nature. 523(7598):201-206, (2016).