University of Wisconsin–Madison
College of Agriculture and Life Sciences | School of Medicine and Public Health

Jennifer Laffin

Associate Professor

Pediatrics - Genetics and Metabolism
Research Interests
Human Genetics and Genomics Clinical Genetics and Genomics Chromosome structure and function Molecular genetics Prenatal genetics Postnatal genetics Oncology
Research Fields
Computational, Systems & Synthetic Biology, Development, Evolutionary & Population Genetics, Gene Expression, Genomics & Proteomics, Neuro & Behavioral Genetics, Human, Mouse & Rat

Research Description:
The lab is a clinical laboratory that studies a wide range of human genetic and genomic conditions affecting prenatal and postnatal development, and oncology. Research in the lab focuses on genotype-phenotype correlations to better understand the genetic contribution to human conditions and natural history, as well as the development of clinical tools and workflows for precision and personalized medicine

Representative Publications:
Search PubMed for more publications by Jennifer Laffin

Denu RA, Zasadil LM, Kanugh C, Laffin J, Weaver BA, Burkard ME. Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer. 2016 Jan 29;16:47. doi: 10.1186/s12885-016-2083-x. PubMed PMID: 26832928; PubMed Central PMCID: PMC4734858. Free full textRelated citations

Choudhary A, Zachek B, Lera RF, Zasadil LM, Lasek A, Denu RA, Kim H, Kanugh C, Laffin JJ, Harter JM, Wisinski KB, Saha S, Weaver BA, Burkard ME. Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 2016 Jan;15(1):48-59. doi: 10.1158/1535- 7163.MCT-15-0527. PubMed PMID: 26586723; PubMed Central PMCID: PMC4707107. Cited in PMCRelated citations

Li MM, Monzon FA, Biegel JA, Jobanputra V, Laffin JJ, Levy B, Leon A, Miron P, Rossi MR, Toruner G, Alvarez K, Doho G, Dougherty MJ, Hu X, Kash S, Streck D, Znoyko I, Hagenkord JM, Wolff DJ. A multicenter, cross-platform clinical validation study of cancer cytogenomic arrays. Cancer Genet. 2015 Nov;208(11):525-36. doi: 10.1016/j.cancergen.2015.08.002. PubMed PMID: 26454669. Cited in PMCRelated citations

Scott Schwoerer J, Laffin J, Haun J, Raca G, Friez MJ, Giampietro PF. MECP2 duplication: possible cause of severe phenotype in females. Am J Med Genet A. 2014 Apr;164A(4):1029-34. doi: 10.1002/ajmg.a.36380. PubMed PMID: 24458799. Related citations

Worthey EA, Raca G, Laffin JJ, Wilk BM, Harris JM, Jakielski KJ, Dimmock DP, Strand EA, Shriberg LD. Whole-exome sequencing supports genetic heterogeneity in childhood apraxia of speech. J Neurodev Disord. 2013 Oct 2;5(1):29. doi: 10.1186/1866-1955-5-29. PubMed PMID: 24083349; PubMed Central PMCID: PMC3851280.