Dudley Lamming

Position title: Associate Professor

Email: dlamming@medicine.wisc.edu

Phone: 608-256-1901 x 12861

Biology of aging and age-related diseases, diabetes, cancer, Alzheimer’s disease

MFCB 4147
Ph.D., Harvard University
Research Interests
Biology of aging and age-related diseases, diabetes, obesity, Alzheimer’s disease
Research Fields
Biology of Aging, Cell Signaling, Human and mouse

Research Description:
Our goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. Rapamycin, an inhibitor of the protein kinase mTOR, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions may provide insight into the treatment of age-related diseases, including diabetes, obesity, and Alzheimer’s disease.

Representative Publications:
Search PubMed for more publications by Dudley Lamming

Green CL, Pak HH, Richardson NE, Flores V, Yu D, Tomasiewicz JL, Dumas SN, Kredell K, Fan JW, Kirsh C, Chaiyakul K, Murphy ME, Babygirija R, Barrett-Wilt GA, Rabinowitz J, Ong IM, Jang C, Simcox J, Lamming DW. Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction. Cell Metab. 2022 Feb 1;34(2):209-226.e5. doi: 10.1016/j.cmet.2021.12.018. PMID: 35108511; PMCID: PMC8865085.

Pak HH, Haws SA, Green CL, Koller M, Lavarias MT, Richardson NE, Yang SE, Dumas SN, Sonsalla M, Bray L, Johnson M, Barnes S, Darley-Usmar V, Zhang J, Yen CE, Denu JM, Lamming DW. Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice. Nat Metab. 2021 Oct;3(10):1327-1341. doi: 10.1038/s42255-021-00466-9. Epub 2021 Oct 18. PMID: 34663973; PMCID: PMC8544824.

Yu D, Richardson NE, Green CL, Spicer AB, Murphy ME, Flores V, Jang C, Kasza I, Nikodemova M, Wakai MH, Tomasiewicz JL, Yang SE, Miller BR, Pak HH, Brinkman JA, Rojas JM, Quinn WJ 3rd, Cheng EP, Konon EN, Haider LR, Finke M, Sonsalla M, Alexander CM, Rabinowitz JD, Baur JA, Malecki KC, Lamming DW. The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. Cell Metab. 2021 May 4;33(5):905-922.e6. doi: 10.1016/j.cmet.2021.03.025. Epub 2021 Apr 21. PMID: 33887198; PMCID: PMC8102360.

Richardson NE, Konon EN, Schuster HS, Mitchell AT, Boyle C, Rodgers AC, Finke M, Haider LR, Yu D, Flores V, Pak HH, Ahmad S, Ahmed S, Radcliff A, Wu J, Williams EM, Abdi L, Sherman DS, Hacker T, Lamming DW. Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice. Nat Aging. 2021 Jan;1(1):73-86. doi: 10.1038/s43587-020-00006-2. Epub 2021 Jan 14. PMID: 33796866; PMCID: PMC8009080.