What do you investigate? Mechanisms involved in Retinal Aging
What did you want to be as a kid? Scientist
What is your favorite thing about Madison? Food and Parks Scene
Where do you see yourself in ten years? Faculty member with tenure (fingers crossed!!!)
What are your hobbies? kayaking, camping, hiking, doing crossword puzzles, traveling
What do you like to cook? I like to cook, but I am not very good at it.
Do you have any pets? Hound/Terrier Mix named Peaches
Do you collect anything? vinyl records, flying pig merchandise
Publications
Landowski M, Grindel S, Hao Y, Ikeda S, Bowes Rickman C, Ikeda A. A Protocol to Evaluate and Quantify Retinal Pigmented Epithelium Pathologies in Mouse Models of Age-Related Macular Degeneration. J Vis Exp, 2023 Mar 10, (193). PMID: 36971449.
Landowski M, Bhute VJ, Grindel S, Haugstad Z, Gyening YK, Tytanic M, Brush RS, Moyer LJ, Nelson DW, Davis CR, Yen CE, Ikeda S, Agbaga MP, Ikeda A. Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism. Commun Biol, 2023 Jan 4, 6(1):8. PMID: 36599953.
Landowski M*, Bhute VJ*, Takimoto T, Grindel S, Shahi PK, Pattnaik BR, Ikeda S, Ikeda A. A Mutation in Transmembrane protein 135 Impairs Lipid Metabolism in Mouse Eyecups. Sci Rep, 2022 Jan 14, 12(1): 756. PMID: 35031662. (*Denotes shared first authorship)
Landowski M and Bowes Rickman C. Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models. J Ocul Pharmacol Ther, 2020 Jan, 38:3-32. PMID: 34788573.
Landowski M, Grindel S, Shahi PK, Johnson A, Western D, Race A, Shi F, Benson J, Gao M, Santoirre E, Lee WH, Ikeda S, Pattnaik BR, Ikeda A (2020) Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice. Invest Ophthalmol Vis Sci, 2020 Oct 1, 61(12):16. PMID: 33064130.
Kelly UL, Grigsby D, Cady MA, Landowski M, Skiba NP, Liu J, Remaley AT, Klingeborn M, Bowes Rickman C. High Density Lipoproteins are a Potential Therapeutic Target for Age-related Macular Degeneration. J Biol Chem, 2020 Sep 25, 295(39):13601-13616. PMID: 32737203.
Macke EL, Henningsen E, Jessen E, Zumwalde NA, Landowski M, Western DE, Lee WH, Liu C, Gruenke NP, Doebley AL, Miller S, Pattnaik B, Ikeda S, Gumperz JE, Ikeda A. Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in skt Mice. Genetics, 2010 Jan 1, 214(1):121-134. PMID: 31754016.
Landowski M, Kelly U, Klingborn M, Groelle M, Ding JD, Grigsby D, Bowes Rickman, C. Human Complement Factor H Y402H Polymorphism Causes an Age-related Macular Degeneration Phenotype and Lipoprotein Dysregulation in Mice. PNAS, 2019 Feb 26, 116(9):3703-3711. PMID: 30808757.
Toomey CB*, Landowski M*, Klingeborn M, Kelly U, Deans J, Dong H, Harrabi O, Van Blarcom T, Yeung YA, Grishanin R, Lin JC, Saban DR, Bowes Rickman C. Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci, 2018 Feb 1, 59(2):662-673. PMID: 29392311. (*Denotes shared first authorship)
Ding JD, Kelly U, Landowski M, Toomey CB, Groelle M, Miller C, Smith SG, Klingeborn M, Singhapricha T, Jiang H, Frank MM, Bowes Rickman C. Expression of human complement factor H prevents age-related macular degeneration-like retinal damage and kidney abnormalities in aged Cfh knockout mice. Am J Pathol, 2015 Jan, 185(1):29-42. PMID: 25447048.
Vlachos A, Farrar JE, Atsidaftos E, Muir E, Narla A, Markello TC, Singh SA, Landowski M, Gazda HT, Blanc L, Liu JM, Ellis SR, Arceci RJ, Ebert BL, Bodine DM, Lipton JM. Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q- syndrome. Blood, 2013 Oct 3, 122(14):2487-90. PMID: 23943650.
Landowski M, O’Donohue MF, Buros C, Ghazvinian R, Montel-Lehry N, Vlachos A, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Glader B, Atsidaftos E, Lipton JM, Beggs AH, Gleizes PE, Gazda HT. Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. Hum Genet, 2013 Nov, 132(11):1265-74. PMID: 23812780.
Gazda HT, Preti M, Sheen MR, O’Donohue MF, Vlachos A, Davies SM, Kattamis A, Doherty L, Landowski M, Buros C, Ghazvinian R, Sieff CA, Newburger PE, Niewiadomska E, Matysiak M, Glader B, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH. Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blackfan anemia. Hum Mutat, 2012 Jul, 33(7):1037-44. PMID: 22431104.
Jaskula-Sztul R, Pisarnturakit P, Landowski M, Chen H, Kunnimalaiyaan M. Expression of the active Notch1 decreases MTC tumor growth in vivo. J Surg Res, 2011 Nov, 171(1):23-7. PMID: 21571316.
Boria I, Garelli E, Gazda HT, Aspesi A, Quarello P, Pavesi E, Ferrante D, Meerpohl JJ, Kartal M, Da Costa L, Proust A, Leblanc T, Simansour M, Dahl N, Fröjmark AS, Pospisilova D, Cmejla R, Beggs AH, Sheen MR, Landowski M, Buros CM, Clinton CM, Dobson LJ, Vlachos A, Atsidaftos E, Lipton JM, Ellis SR, Ramenghi U, Dianzani I. The ribosomal basis of Diamond-Blackfan Anemia: mutation and database update. Hum Mutat, 2010 Dec, 31(12):1269-79. PMID: 20960466.