Position title: Assistant Professor
Epigenetic Mechanisms in Development and Cancer
- 4214 Biochemical Sciences Building
- Ph.D.,University of California, Berkeley, Postdoctoral Research: Rockefeller University
- Lab Website
- Biomolecular Chemistry
- Research Interests
- Epigenetic Mechanisms in Development and Cancer
- Research Fields
- Chromatin Biology, Disease Biology, Development, Human and Mouse
My research program is rooted in the idea that eukaryotic chromatin, the physiologically relevant form of genomes, contains an indexing system that represents a fundamental regulatory mechanism. Covalent modifications to both DNA and histone proteins allow chromatin to act as a dynamic information hub that integrates diverse biochemical stimuli to regulate genomic DNA access and ultimately establish and maintain cellular identity. Aberrant chromatin regulation, as a consequence of mutation or abnormal signaling is associated with many diseases, especially cancer. The identification of oncogenic mutations has led to the emerging view of “driver mutations” in chromatin regulators underlying many human cancers. My research is aimed at defining how changes in chromatin structure aid in the establishment and maintenance of gene expression programs involved in normal development and tumorigenesis.
Jain SU, Rashoff AQ, Krabbenhoft SD, Hoelper D, Do TJ, Gibson TJ, Lundgren SM, Bondra ER, Deshmukh S, Harutyunyan AS, Juretic N, Jabado N, Harrison MM, Lewis PW.
H3 K27M and EZHIP impede H3K27-methylation spreading by inhibiting allosterically stimulated PRC2.
Molecular Cell, 2020 Nov 19;80(4):726-735
Jain SU, Khazaei S, Marchione DM, Lundgren SM, Wang X, Weinberg DN, Deshmukh S, Juretic N, Lu C, Allis CD, Garcia BA, Jabado N, Lewis PW.
Histone H3.3 G34 mutations promote aberrant PRC2 activity to drive tumor progression.
Proc Natl Acad Sci, 2020 Nov 3;117(44):27354-27364
Jain SU, Do TJ, Lund PJ, Cieslik M, Diehl KL, Rashoff AQ, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW.
PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.
Nature Communications, 2019 May 13;(10):2146
Hoelper D, Huang H, Jain A, Patel DJ, Lewis PW.
Structural and mechanistic insights into ATRX-dependent and –independent functions of the histone chaperone DAXX.
Nature Communications, 2017 Oct 30;8(1):1193
Jayaram H, Hoelper D, Jain SU, Canton N, Lundgren SM, Poy F, Allis CD, Cummings R, Bellon S, Lewis PW.
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by lysine-9-to-methionine mutation on histone H3.
Proc Natl Acad Sci., 2016 May 31;113(22):6182-7
Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, DeJay N, Papillon S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW.
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.
Science, 2016 May 13;352(6287):844-9