Amy Moser

Research Description:
The research areas under study in my laboratory are: 1) Identification of genes involved in mammary tumor susceptibility and resistance, 2) The role of the Apc (adenomatous polyposis coli) gene in mammary gland development and maintenance, and 3) Characterization of the molecular events that occur during neoplastic transformation of the mammary gland in vivo. For these studies we utilize mice carrying a mutant allele of Apc, Min (multiple intestinal neoplasia). Min/+ mice are predisposed to intestinal and mammary neoplasia. We have found that genetic background can affect the susceptibility to both mammary and intestinal tumor formation. We are concentrating on the role of these modifier genes in the mammary gland. We are using genetic approaches to identify and characterize loci involved in susceptibility to mammary neoplasia.

Representative Publications:
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Kohlhepp RL. Hegge LF. and Moser AR. 2001. The ROSA26 LacZ-neo(R) insertion confers resistance to mammary tumors in Apc(Min/+) mice. Mammalian Genome. 12(8):606-11.

Karabinis ME. Larson D. Barlow C. Wynshaw-Boris A. Moser AR. 2001. Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice. Carcinogenesis. 22(2):343-6.

Kohlhepp RL. Hegge LF. Nett JE. Moser AR. 2000. ROSA26 mice carry a modifier of Min-induced mammary and intestinal tumor development. Mammalian Genome. 11(12):1058-62.

Moser, A.R., Luongo, C., Gould, K.A., McNeley, M.K., Shoemaker, A.R., and Dove, W.F. 1995. ApcMin: A Mouse Model for Intestinal and Mammary Tumorigenesis. Eur J Cancer 31A:1061-1064.

Moser, A.R., Mattes, E.M., Dove, W.F., Lindstrom, M.J., Haag, J.D., and Gould, M.N. 1993. ApcMin, a Mutation in the Murine Apc Gene, Predisposes to Mammary Carcinomas and Focal Alveolar Hyperplasias. Proc Natl Acad Sci USA 90:8977-8981.

Dietrich, W., Lander, E., Smith, J.S., Moser, A.R., Gould, K.A., Luongo, C., Borenstein, N., and Dove, W.F. 1993. Genetic Identification of Mom-1, a Major Modifier Locus Affecting Min-induced Intestinal Neoplasia in the Mouse. Cell 71:631-639.