David Schwartz
Position title: Professor
Email: dcschwartz@wisc.edu
Phone: 608-265-0546
Address:
Genetics and Chemistry
Discovery of fundamental molecular phenomena, which are harnessed within fully integrated systems for comprehensive genome analysis; creation of a cell-free system (“GenSyn”) for the direct fabrication of synthetic chromosomes, which adapt/advance micro- and nanofluidics technologies previously developed for genome analysis by the Schwartz group
- Address
- 5434 Genetics/Biotech
- Education
- Ph.D., Columbia University, 1985
- Department
- Genetics and Chemistry
- Research Interests
- Scalable discovery of human and cancer structural variation through invention and applications of single molecule systems.
- Research Fields
- Disease Biology, Computational, Systems & Synthetic Biology, Gene Expression, Genomics & Proteomics, Bacteria, Fungi, Human, mouse & rat, Plants
Research Description:
The Schwartz group (Genetics; Chemistry) discovers fundamental molecular phenomena, which are harnessed within fully integrated systems for comprehensive genome analysis. Development of genome analysis systems entails nanotechnology, polymer dynamics and simulations, nucleic acid chemistries, electronic detection, surface science, nano/micro fabrication, optics, machine vision, statistics, and computer science. New genome analysis systems (Optical Mapping—the first single molecule system for whole genome analysis, Nanocoding, Optical Sequencing, and Fluoroscanning) employ single molecule analytes and are aimed at discovery of structural variation and its role in human germline variation [30] and cancer genomics. Because the Schwartz group creates genomic systems featuring high rates of data acquisition, they are designed with a high degree of automation for segueing into bioinformatics pipelines that the group also builds. Such pipelines are powered by cluster computing and offer suites of analysis tools facilitated by advanced user interfaces. New research directions include creation of a cell-free system (GenSyn”) for the direct fabrication of synthetic chromosomes, which adapt/advance micro- and nanofluidics technologies previously developed for genome analysis by the Schwartz group.
Representative Publications:
Search PubMed for more publications by David Schwartz
Schwartz, David C., Biophysics and the Genomic Sciences, Biophysical Journal, invited Perspective for the special issue on the inaugural meeting – Genome Biophysics Jul 30. pii: S0006-3495(19)30627-7. doi: 10.1016/j.bpj.2019.07.038. [Epub ahead of print] 2019. PMC6895736.
Dong-Wook, P., Tsvid, G., Hernandez-Ortiz, J.P., Schwartz, D.C., and Ma, Z. Trench-field effect transistors integrated in a microfluidic channel and design considerations for charge detection, Applied Phys. Lett., 2022, in press.
Krerowicz, S.J.W., Hernandez-Ortiz, J.P., and Schwartz, D.C., Microscale Objects via Restructuring of Large, Double-Stranded DNA Molecules. ACS Appl Mater Interfaces, 10(48): 41215-41223 Dec 5 2018. doi: 10.1021/acsami.8b18157
Kounovsky-Shafer, K. Hernandez-Ortiz, J.P., Potamousis, K., Tsvid, G., Place, M., Ravindran, P., Kyubong, J., Zhou, S., Odijk, T., de Pablo, J. J. and Schwartz, D.C. Electrostatic confinement and manipulation of DNA molecules for genome analysis, Proc. Nat’l. Acad. Sci. USA, 2017 Dec 19;114(51):13400-13405. PMCID: PMC5754773.
Lequieu, J., Schwartz, D.C., and de Pablo, J.J, In Silico Evidence for Sequence-Dependent Nucleosome Sliding, PNAS USA, 114 (44): E9197-E9205. doi: 10.1073/pnas.1705685114. Epub Oct. 18, 2017.
Gupta, A., Place, M., Goldstein, S., Sarkar, D., Zhou, S., Potamousis, K., Kim, J., Flanagan, C., Li, Y., Newton, M.A., Callander, N.S., Hematti, P., Bresnick, E.H., Ma, J., Asimakopoulos, F., and Schwartz, D.C., Single molecule analysis reveals widespread structural variation and clonal evolution in multiple myeloma, Proc. Nat’l. Acad. Sci. USA,112 (25): 7689-94. doi: 10.1073/pnas.1418577112. Epub 2015 Jun 8 (one of the “Most-Read Articles during June 2015”). PMCID: PMC4485118