Ahna Skop
Position title: Professor
Email: skop@wisc.edu
Phone: 608-262-1593
Address:
Genetics, Medical Genetics
Affiliate appointments in Life Science Communication and Art
Newly appreciated signaling organelle called the midbody (MB) and the midbody remnant (MBR)
- Address
- 2426 Genetics/Biotech
- Education
- Ph.D. (2000) University of Wisconsin-Madison, Postdoctoral Research: HHMI, UC-Berkeley, 2000-2004, Sabbatical: Fred Hutch Cancer Center (Spring 2022)
- Lab Website
- http://skoplab.weebly.com/
- Department
- Genetics, Medical Genetics
- Research Interests
- Newly appreciated signaling organelle called the midbody (MB) and the midbody remnant (MBR)
- Research Fields
- Disease Biology, Cell Biology, Development, Gene Expression, Genomics and Proteomics, Humans
- Schedule a chat with Ahna
- https://calendly.com/skop
Research Description:
My lab studies a large actively translating RNA-based extracellular vesicle that is generated during mitosis that is called the midbody remnant or MBR. The MBR is generated by all mitotic cells but more so by highly proliferative cells like in cancer. So these newly appreciated signaling organelles are important in cancer diagnostics. My lab is currently trying to determine the RNAs that reside in different cell type MBRs and whether or not they have unique and common RNAs used in cell-cell communication. This information will help us understand how perhaps cancer spreads. My lab is also collaborating with Justin Wolter’s lab to determine the role of MBRs in autism.
Representative Publications:
Search PubMed for a publications by Ahna Skop
Park S, Dahn R, Kurt E, Presle A, VanDenHeuvel K, Moravec C, Jambhekar A, Olukoga O, Shepherd J, Echard A, Blower M, Skop AR. The mammalian midbody and midbody remnant are assembly sites for RNA and localized translation. Dev Cell. 2023 Oct 9;58(19):1917-1932.e6. doi: 10.1016/j.devcel.2023.07.009. Epub 2023 Aug 7. PMID: 37552987; PMCID: PMC10592306.
Jung GI, Londoño-Vásquez D, Park S, Skop AR, Balboula AZ, Schindler K. An oocyte meiotic midbody cap is required for developmental competence in mice. Nat Commun. 2023 Nov 16;14(1):7419. doi: 10.1038/s41467-023-43288-x. PMID: 37973997; PMCID: PMC10654508.
Park S, Patel SA, Torr EE, Dureke AN, McIntyre AM, Skop AR. A protocol for isolating and imaging large extracellular vesicles or midbody remnants from mammalian cell culture. STAR Protoc. 2023 Dec 15;4(4):102562. doi: 10.1016/j.xpro.2023.102562. Epub 2023 Sep 9. PMID: 37690025; PMCID: PMC10500451.