Han Wang

Position title: Assistant Professor

Email: han.wang@wisc.edu

Phone: (608)-262-3336

Integrative Biology
Molecular and Circuit Mechanisms of Sleep and Behaviors in C. elegans; Development of Novel Genetic Tools

115 iBio Research Building, 1117 W Johnson St., Madison, WI 53706
Ph.D., University of Southern California (2007-2013) & Postdoctoral Research, California Institute of Technology (2014-2019)
Lab Website
Integrative Biology
Research Interests
Molecular and Circuit Mechanisms of Sleep and Behaviors in C. elegans; Development of Novel Genetic Tools
Research Fields
Neuroscience, Genetics, Genomics, Sleep, Behavior, Neuropeptide signaling, C. elegans

Research Description:
The Wang lab is interested in studying how the brain controls behaviors. Our current focus is to understand sleep. Despite being an evolutionarily conserved behavior, sleep remains one of the most intriguing mysteries in biology. We use C. elegans as a model system and exploit its advantages (powerful genetics, optical transparency, and a small nervous system with well-defined anatomical connectivity) to understand the molecular, cellular, and circuit mechanisms underlying sleep. We also are interested in understanding the development of the sleep circuit. We take an integrative approach by combining classic molecular and genetic tools with state-of-the-art techniques, such as optogenetics, in vivo live imaging, genome editing, automated behavioral tracking, and next-generation sequencing. In parallel, we also develop novel genetic tools to precisely control transgene expression and manipulate genome.

Representative Publications:
Search PubMed for more publications by Han Wang

Wang, H. , *, Park, H.*, Liu, J., and Sternberg P.W.† (2018). An Efficient Genome Editing Pipeline to Generate Null Mutants in Caenorhabditis elegans Using CRISPR/Cas9. G3: Genes, Genomes, Genetics. 8, 3607–3616.

Wang, H. , *, Liu, J.*, Yuet, K.P., Hill, A. J., and Sternberg, P.W.† (2018). Split cGAL, an Intersectional Strategy Using a Split Intein for Refined Spatiotemporal Transgene Control in C. elegans. Proceedings of the National Academy of Sciences. 115, 3900–3905.

Wang, H.*, Liu, J.*, Gharib, S., Chai, C.M., Schwarz, E.M., Pokala, N., and Sternberg, P.W. (2017). cGAL, a Temperature-robust GAL4-UAS System for Caenorhabditis elegans. Nature Methods. 14, 145–148.

Nath, R.D., Chow, E.S., Wang, H., Schwarz, E.M., and Sternberg, P.W. (2016). C. elegans Stress-Induced Sleep Emerges from the Collective Action of Multiple Neuropeptides. Current Biology. 26, 2446–2455