Beth A. Weaver

Position title: Professor

Phone: 608-263-5309

Address:
Cell and Regenerative Biology; Oncology/McArdle Laboratory for Cancer Research
Mitosis, Aneuploidy, Chromosomal instability, Cancer

Address: 6109 WIMR I
Education: PhD University of California, San Diego 2003. post-doc Ludwig Institute for Cancer Research, La Jolla, CA 2008
Department: Cell and Regenerative Biology - McArdle Laboratory for Cancer Research
Research Interests: Mitosis, Aneuploidy, Chromosomal instability, Cancer
Research Fields: Disease Biology, Cell Biology, Humans, Mouse and other Mammals
Lab Website: https://weaver.crb.wisc.edu/

Research Description:

My lab studies the regulation of chromosome segregation during mitosis and the impact of chromosome missegregation on tumors. We are interested in determining mechanisms of proper chromosome segregation, defining how chemotherapeutic agents and radiation disrupt proper mitosis, and characterizing the consequences of chromosome segregation errors on tumor promotion, suppression, and response to therapy.

Representative Publications:

Search for more publications by Beth Weaver

Copeland SE, Snow SM, Wan J, Matkowskyj KA, Halberg RB, Weaver BA. 2024. MAD1 upregulation sensitizes to inflammation-mediated tumor formation. PLOS Genetics. https://doi.org/10.1371/journal.pgen.1011437.

Tucker JB, Carlsen CL, Scribano CM, Pattaswamy SM, Burkard ME, Weaver BA. 2024. CENP-E inhibition induces chromosomal instability and synergizes with diverse microtubule-targeting agents in breast cancer. Cancer Res. doi: 10.1158/0008-5472.CAN-23-3332.

Lynch AR, Bradford S, Zhou AS, Oxendine K, Henderson L, Horner VL, Weaver BA, Burkard ME. 2024. A survey of chromosomal instability measures across mechanistic models. Proc Natl Acad Sci USA 121(16):e2309621121. doi.org/10.1073/pnas.230962112.

Zhou AS, Tucker JB, Scribano CM, Lynch AR, Carlsen CL, Pop-Vicas ST, Pattaswamy SM, Burkard ME, Weaver BA. 2023. Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles. PLOS Biology. 21(10):e3002339. doi: 10.1371/journal.pbio.3002339.

Cosper PF*, Funk LC*, Lee DL, Williams SD, Kimple RJ, Lambert PF, and Weaver BA. HPV16 E6 induces chromosomal instability due to polar chromosomes caused by E6AP-dependent degradation of the mitotic kinesin CENP-E. 2023. Proc Natl Acad Sci U S A 120(14):e2216700120. doi: 10.1073/pnas.2216700120.

Lynch AR, Arp NL, Zhou AS, Weaver BA, Burkard ME. Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference. Elife. 2022 Apr 5;11. doi: 10.7554/eLife.69799. PubMed PMID: 35380536; PubMed Central PMCID: PMC9054132.

Cosper PF, Copeland SE, Tucker JB, Weaver BA. Chromosome Missegregation as a Modulator of Radiation Sensitivity. Semin Radiat Oncol. 2022 Jan;32(1):54-63. doi: 10.1016/j.semradonc.2021.09.002. Review. PubMed PMID: 34861996; PubMed Central PMCID: PMC8883596.

Scribano CM, Wan J, Esbona K, Tucker JB, Lasek A, Zhou AS, Zasadil LM, Molini R, Fitzgerald J, Lager AM, Laffin JJ, Correia-Staudt K, Wisinski KB, Tevaarwerk AJ, O’Regan R, McGregor SM, Fowler AM, Chappell RJ, Bugni TS, Burkard ME, Weaver BA. Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel. Sci Transl Med. 2021 Sep 8;13(610):eabd4811. doi: 10.1126/scitranslmed.abd4811. Epub 2021 Sep 8. PubMed PMID: 34516829; PubMed Central PMCID: PMC8612166.

Funk LC, Wan J, Ryan SD, Kaur C, Sullivan R, Roopra A, Weaver BA. p53 Is Not Required for High CIN to Induce Tumor Suppression. Mol Cancer Res. 2021 Jan;19(1):112-123. doi: 10.1158/1541-7786.MCR-20-0488. Epub 2020 Sep 18. PubMed PMID: 32948674; PubMed Central PMCID: PMC7810023.

Burkard ME, Weaver BA. Tuning Chromosomal Instability to Optimize Tumor Fitness. Cancer Discov. 2017 Feb;7(2):134-136. doi: 10.1158/2159-8290.CD-16-1415. PubMed PMID: 28167614; PubMed Central PMCID: PMC5312840.

Zasadil LM, Andersen KA, Yeum D, Rocque GB, Wilke LG, Tevaarwerk AJ, Raines RT, Burkard ME, Weaver BA. Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci Transl Med. 2014 Mar 26;6(229):229ra43. doi: 10.1126/scitranslmed.3007965. PubMed PMID: 24670687; PubMed Central PMCID: PMC4176609.

*equal contribution

Tucker JB, Varela RG, Lera RF, Burkard ME, Weaver BA. 2023. Misaligned chromosomes are a major mechanism of chromosomal instability in breast cancer. Cancer Research Communications 3(1):54-65. doi.org/10.1158/2767-9764.CRC-22-0302.

Britigan EMC, Wan J, Lasek A, Funk LC, Wang L, Audhya A, Burkard ME, Roopra A, Weaver BA. 2022. Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability. Front Cell Dev Biol 13;10:1018161. doi: 10.3389/fcell.2022.1018161.