Beth A. Weaver
Position title: Associate Professor
Email: baweaver@wisc.edu
Phone: 608-263-5309
Address:
Cell and Regenerative Biology; Oncology/McArdle Laboratory for Cancer Research
Mitosis, Aneuploidy, Chromosomal instability, Cancer
- Address
- 6109 WIMR I
- Education
- PhD University of California, San Diego 2003. post-doc Ludwig Institute for Cancer Research, La Jolla, CA 2008
- Department
- Cell and Regenerative Biology - McArdle Laboratory for Cancer Research
- Research Interests
- Mitosis, Aneuploidy, Chromosomal instability, Cancer
- Research Fields
- Disease Biology, Cell Biology, Humans, Mouse and other Mammals
- Lab Website
- https://weaver.crb.wisc.edu/
Research Description:
My lab studies the regulation of chromosome segregation during mitosis and the impact of chromosome missegregation on tumors. We are interested in determining mechanisms of proper chromosome segregation, defining how chemotherapeutic agents and radiation disrupt proper mitosis, and characterizing the consequences of chromosome segregation errors on tumor promotion, suppression, and response to therapy.
Representative Publications:
Search for more publications by Beth Weaver
Lynch AR, Arp NL, Zhou AS, Weaver BA, Burkard ME. Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference. Elife. 2022 Apr 5;11. doi: 10.7554/eLife.69799. PubMed PMID: 35380536; PubMed Central PMCID: PMC9054132.
Cosper PF, Copeland SE, Tucker JB, Weaver BA. Chromosome Missegregation as a Modulator of Radiation Sensitivity. Semin Radiat Oncol. 2022 Jan;32(1):54-63. doi: 10.1016/j.semradonc.2021.09.002. Review. PubMed PMID: 34861996; PubMed Central PMCID: PMC8883596.
Scribano CM, Wan J, Esbona K, Tucker JB, Lasek A, Zhou AS, Zasadil LM, Molini R, Fitzgerald J, Lager AM, Laffin JJ, Correia-Staudt K, Wisinski KB, Tevaarwerk AJ, O’Regan R, McGregor SM, Fowler AM, Chappell RJ, Bugni TS, Burkard ME, Weaver BA. Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel. Sci Transl Med. 2021 Sep 8;13(610):eabd4811. doi: 10.1126/scitranslmed.abd4811. Epub 2021 Sep 8. PubMed PMID: 34516829; PubMed Central PMCID: PMC8612166.
Funk LC, Wan J, Ryan SD, Kaur C, Sullivan R, Roopra A, Weaver BA. p53 Is Not Required for High CIN to Induce Tumor Suppression. Mol Cancer Res. 2021 Jan;19(1):112-123. doi: 10.1158/1541-7786.MCR-20-0488. Epub 2020 Sep 18. PubMed PMID: 32948674; PubMed Central PMCID: PMC7810023.
Burkard ME, Weaver BA. Tuning Chromosomal Instability to Optimize Tumor Fitness. Cancer Discov. 2017 Feb;7(2):134-136. doi: 10.1158/2159-8290.CD-16-1415. PubMed PMID: 28167614; PubMed Central PMCID: PMC5312840.
Zasadil LM, Andersen KA, Yeum D, Rocque GB, Wilke LG, Tevaarwerk AJ, Raines RT, Burkard ME, Weaver BA. Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci Transl Med. 2014 Mar 26;6(229):229ra43. doi: 10.1126/scitranslmed.3007965. PubMed PMID: 24670687; PubMed Central PMCID: PMC4176609.